The p53 Tumor Suppressor Causes Congenital Malformations in ...

Gene Expression Literature Summary - MGI

... The p53 tumor suppressor causes congenital malformations in Rpl24-deficient mice and promotes their survival. Mol Cell Biol. 2009 May;29(10):2489-504. 16 ...

The role of p53 in developmental syndromes - Oxford Academic

While it is well appreciated that loss of the p53 tumor suppressor protein promotes cancer, growing evidence indicates that increased p53 activity underlies the ...

Teratogen-induced eye defects mediated by p53-dependent apoptosis

Conclusion We conclude that teratogen induction of p53-dependent apoptosis in the developing embryo is positively coupled to the determination of congenital eye ...

Germline Mutations of the p53 Tumor-Suppressor Gene in Children ...

Acquired mutations in the p53 tumor-suppressor gene have been detected in several human cancers, including colon, breast, and lung cancer.

Activation of the tumor suppressor p53 upon impairment of ribosome ...

Genetic inactivation of p53 in these mice largely rescued all pathological phenotypes, suggesting that they are caused by p53. However, in the absence of p53 a ...

TP53 gene: MedlinePlus Genetics

The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor.

p53 and disease: when the guardian angel fails - Nature

The p53 tumor suppressor gene (TP53) is mutated more often in human cancers than any other gene yet reported. Of importance, it is mutated ...

The Role of the p53 Tumor Suppressor Gene in Squamous Cell ...

Mutations in the p53 tumor suppressor gene have been shown to be one of the most common genetic abnormalities in human cancers, and the published literature ...

Mutant p53 in cancer: from molecular mechanism to therapeutic ...

TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human cancers. Aside from losing its tumor suppressor function, ...

TP53 Genetic Test: MedlinePlus Medical Test

As a result, your cells may grow out of control, which can lead to tumors and cancer. Changes in your TP53 gene can be acquired or inherited.

O6-methylguanine–induced transcriptional mutagenesis reduces ...

This resulted in the loss of functional cell-cycle checkpoints and in impaired activation of apoptosis, both canonical p53 tumor-suppressor ...