The role of CD4 CAR T cells in cancer immunotherapy

Uncovering the Role of CD4+ CAR T Cells in Cancer Immunotherapy

CD4+ CAR T-cell production of IFNγ creates a cytokine field that can act at a distance to kill both antigen-positive and -negative tumor cells ...

The role of CD4+ CAR T cells in cancer immunotherapy - Bove

Recent clinical studies have highlighted some unexpected mechanisms by which CD4+ CAR T cells contribute to tumour control. The clinical ...

The role of CD4+ CAR T cells in cancer immunotherapy - PMC

Recent clinical studies have highlighted some unexpected mechanisms by which CD4+ CAR T cells contribute to tumour control. The clinical importance of cytotoxic ...

Uncovering the Role of CD4 + CAR T Cells in Cancer Immunotherapy

“Killer” CD8+ CAR T cells directly eliminate antigen-positive tumor cells through a perforin-dependent mechanism; however, maintenance of their ...

Revisiting the role of CD4+ T cells in cancer immunotherapy—new ...

CD4+ T cells primarily mediate anti-tumour immunity by providing help for CD8+ CTL and antibody responses, as well as via secretion of effector ...

Uncovering the Role of CD4 CAR T Cells in Cancer Immunotherapy

Chimeric antigen receptor (CAR) T-cell therapy has transformed clinical care against blood malignancies and is seeing encouraging.

CD4 CAR-T cells targeting CD19 play a key role in exacerbating ...

However, the relative contribution of CD4 and CD8 CAR-T cell subsets to cytokine release syndrome (CRS) development has not been thoroughly investigated yet.

Review article Role of T cells in cancer immunotherapy

Immune checkpoint inhibitors are a potential strategy for cancer cells to bypass immune cell attacks. CD4+ T cells can be primed through therapeutic vaccination ...

CD4+ T cells in antitumor immunity: Trends in Cancer - Cell Press

Clearly, CD4+ T cells play an important role in developing and sustaining antitumor immunity in the context of immunotherapy. Thus, ...

Roles of CD4+ T cells as mediators of antitumor immunity - Frontiers

Determining such mechanisms is of importance for cancer treatment as they will provide insight into when engaging CD4+ T cells, either alone or alongside CD8+ T ...

Key role of CD4+ T cells in determining CD8 function during CAR-T ...

Chimeric antigen receptor (CAR)-T cell therapies have led to durable remissions in cancer patients who are at high risk of relapse and death.1 2 However, ...

The role of CD4 T cells in rejection of solid tumors - ScienceDirect.com

The focus in cancer immunotherapy has mainly been on CD8 T cells, as they can directly recognize cancer cells. CD4 T cells have largely been neglected, ...

Harnessing Antitumor CD4+ T Cells for Cancer Immunotherapy - MDPI

Diverse evidence revealed that CD4+ T cells play an important role in antitumor immunity by promoting or suppressing cytotoxic T cell responses.

Cancer: CAR T cell function scrutinized to improve immunotherapy

The results have revealed that CD4+ CAR T cells and CD8+ CAR T cells exhibit highly complementary functions, specializing respectively in ...

A major role for CD4 + T cells in driving cytokine release syndrome ...

Chimeric antigen receptor (CAR) T cells have shown successful clinical applications in the treatment of B cell malignancies, but the occurrence ...

Glioblastoma-targeted CD4 + CAR T cells mediate ... - JCI Insight

CD4+ T cells have long been identified for their dual functions as helper cells to augment the immune response of CD8+ T cells and to directly ...

CD4+ CAR T-cell exhaustion associated with early relapse of ...

Recently, chimeric antigen receptor (CAR) T cells targeting B-cell maturation antigen (BCMA) has been established as a treatment option for ...

Uncovering the Role of CD4+ CAR T Cells in Cancer Immunotherapy

Cytolytic Activity of CAR T Cells and Maintenance of Their CD4+ Subset Is Critical for Optimal Antit... ... Correlative studies of clinical studies for ...

CAR-T Cell Performance: How to Improve Their Persistence?

One of the major issues of using CAR-T cells for the treatment of solid tumors is the low persistence of the cells infused within the tumor mass (12). Long-term ...

CD19 CAR–T cells of defined CD4+:CD8+ composition in adult ... - JCI

Risk-stratified CAR–T cell dosing based on BM disease burden decreased toxicity. CD8+ T cell–mediated anti-CAR transgene product immune ...