The role of adenosine tone and adenosine receptors in Huntington's ...

The Role of Adenosine Tone and Adenosine Receptors in ...

Extracellular ATP is rapidly converted to adenosine by a series of ectonucleotidases and extracellular levels of adenosine (adenosinergic tone) is maintained by ...

The Role of Adenosine Tone and Adenosine Receptors in ... - PubMed

Basal levels of adenosine and adenosine receptors are involved in many processes critical for neuronal function and homeostasis, including ...

What Is the Role of Adenosine Tone and Adenosine Receptors in ...

More generally, adenosine tone and adenosine receptors are involved in a number of processes critical for neuronal function and homeostasis, ...

The Role of Adenosine Tone and Adenosine Receptors in ...

Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by a mutation in the IT15 gene that encodes for the huntingtin protein.

The Role of Adenosine Tone and Adenosine Receptors in ...

The Role of Adenosine Tone and Adenosine Receptors in Huntington's Disease. · D. Blum, Y. Chern, +5 authors. P. Popoli · Published in Journal of Caffeine and… 1 ...

Targeting ENT1 and adenosine tone for the treatment of ...

Adenosine homeostasis is abnormal in the striatum of a mouse model of Huntington's disease (R6/2). The levels of adenosine, adenine nucleotides and AMP/ATP ...

What Is the Role of Adenosine Tone and Adenosine Receptors in ...

Huntington's disease (HD) is a devastating hereditary neurodegenerative disorder caused by a CAG mutation within the IT15 gene encoding huntingtin protein.

ddw402.pdf - Oxford Academic

the functions of adenosine receptors in the brain are aberrantly regulated in HD. In addition to function as a neurotransmitter, adenosine.

Adenosine receptors and Huntington's disease - Semantic Scholar

The Adenosine A1 Receptor Agonist Adenosine Amine Congener Exerts a Neuroprotective Effect against the Development of Striatal Lesions and Motor Impairments in ...

Emerging roles of dysregulated adenosine homeostasis in brain ...

A1R and A2AR are the major adenosine receptor subtypes in the brain and can be found in both neurons and glia. In many pathophysiological ...

Adenosine Receptors and Huntington's Disease | Request PDF

Since the first genetic HD model was created almost two decades ago, tremendous progress regarding the function of the adenosine receptors in HD has been made.

Divergent Effects of the Nonselective Adenosine Receptor ... - MDPI

The Role of Adenosine Tone and Adenosine Receptors in Huntington's Disease. J. Caffeine Adenosine Res. 2018, 8, 43–58. [Google Scholar] [CrossRef]; Dhaenens ...

Adenosine A 2A receptors and brain injury: Broad spectrum of ...

It is clear that extracellular adenosine acting at adenosine receptors influences the functional outcome in a broad spectrum of brain injuries, indicating that ...

The Role of Adenosine A2A Receptor, CYP450s, and PPARs in the ...

Adenosine is an endogenous mediator involved in a myriad of physiologic functions, including vascular tone regulation.

Adenosine A2A receptors modulate BDNF both in normal conditions ...

Adenosine A2A receptors modulate BDNF both in normal conditions and in experimental models of Huntington's disease · Abstract · Introduction.

Targeting ENT1 and adenosine tone for the treatment of ...

The treatment of HD is an unmet medical need. Given the important role of adenosine in modulating brain activity, in this study, levels of adenosine and adenine ...

Purinergic Signaling in the Pathophysiology and Treatment of ...

As mentioned above, adenosine mediates its effect through four adenosine receptors (A1, A2A, A2B, and A3). A1R and A2AR are mainly involved in the central ...

Focusing on Adenosine Receptors as a Potential Targeted Therapy ...

All these studies considered the role of adenosine-related specific receptors. The classical autonomic neurotransmitters released from peripheral nerves were ...

Adenosine A(2A) receptors modulate BDNF both in normal ...

Adenosine A(2A) receptors modulate BDNF both in normal conditions and in experimental models of Huntington's disease. R L Potenza. Department of Therapeutic ...

The Role of Adenosine Tone and Adenosine Receptors in ...

Title: The Role of Adenosine Tone and Adenosine Receptors in Huntington's Disease ; Authors: Blum, David · Chern, Yijuang · Domenici, Maria Rosaria · Buée, Luc