The role of cellular reactive oxygen species in cancer chemotherapy

Most chemotherapeutics elevate intracellular levels of reactive oxygen species (ROS), and many can alter redox-homeostasis of cancer cells.

This review outlines the current understanding of the role of ROS in cancer cells during carcinogenesis and during chemotherapy.

ROS in cancer therapy: the bright side of the moon - Nature

Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have evolved as regulators of important signaling ...

Reactive oxygen species in cancer progression and its role in ...

Cancer cells produce more spatially concentrated ROS than normal cells, which hyperactivates the cell signaling pathways required for cellular ...

Reactive oxygen species in cancer: Current findings and future ...

In short, increased ROS levels in response to chemotherapy are crucial for damaging cancer cells and also play a vital role in multidrug ...

Reactive oxygen species (ROS) in cancer pathogenesis and therapy

In this line, now it has become evident that ROS level/concentration is a major factor in the growth, progression and stemness of cancer cells. Moreover, cancer ...

Role of Reactive Oxygen Species in Cancer Progression - MDPI

ROS activate Nrf2 that stimulates Klf9 (Krupple like factor 9), thus activating ERK1/2; and results in an increased ROS production in cancer cells. Thus, a ...

ROS Induced by Chemo- and Targeted Therapy Promote Apoptosis ...

Reactive oxygen species (ROS) are highly reactive molecules that play an important role in cellular homeostasis. Their levels are maintained ...

Implications of reactive oxygen species on cancer formation and its ...

Cancer cells adapt to high concentrations of ROS via antioxidant production and reprogrammed cellular metabolism (eg, the Warburg effect). Because some widely ...

Dual Role of Reactive Oxygen Species and their Application in ...

Infiltration of T cells, NK cells, and M1 macrophages in breast cancer has been reported to prevent tumor development [22]. Furthermore, high levels of ROS ...

Oxidative cell death in cancer: mechanisms and therapeutic ... - Nature

Reactive oxygen species (ROS) are highly reactive oxygen-containing molecules generated as natural byproducts during cellular processes, ...

Reactive oxygen species in cancer cells: Live by the sword, die by ...

Reactive oxygen species (ROS) and cellular oxidant stress have long been associated with cancer. ... These connections are still not fully understood but are ...

Understanding of ROS‐Inducing Strategy in Anticancer Therapy

Redox homeostasis is essential for the maintenance of diverse cellular processes. Cancer cells have higher levels of reactive oxygen species ...

The role of reactive oxygen species in tumor treatment

Reactive oxygen species (ROS) are by-products of aerobic metabolism and can also act as signaling molecules to participate in multiple regulation of ...

Cancer Metabolism: The Role of ROS in DNA Damage and ... - MDPI

Cancer is a huge challenge for people worldwide. High reactive oxygen species (ROS) levels are a recognized hallmark of cancer and an important aspect of ...

Mitochondrial reactive oxygen species and cancer

Mitochondrial-derived reactive oxygen species (mROS) have increasingly been appreciated to function as signaling molecules that modify cellular ...

The role of reactive oxygen species in gastric cancer

Reactive oxygen species (ROS) are highly reactive molecules capable of oxidation and are closely linked to tumor progression by promoting both tumor initiation ...

The role of cellular reactive oxygen species in cancer chemotherapy

He L, He T, Farrar S, Ji L, Liu T, Ma X. Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species. Cell Physiol Biochem. 2017; ...

ROS-Inducing Agents for Cancer Chemotherapy

Abstract. Reactive oxygen species (ROS) play an essential role in maintaining cellular homeostasis, and levels of ROS are regulated by redox ...

Reactive Oxygen Species and Drug Resistance in Cancer ...

Earlier research results showed that ROS might play a direct killing role in their cytotoxicity of chemotherapeutic agents and recombinant human tumor necrosis ...