The role of circadian gene CLOCK in cancer

Roles of circadian clocks in cancer pathogenesis and treatment

It has been well documented that circadian clocks regulate the absorption, distribution, metabolism, and elimination of drugs. Furthermore, ...

Major roles of the circadian clock in cancer - PMC - PubMed Central

The genes regulated by the circadian clock include various oncogenes and tumor suppressor genes, and the core genes of the circadian clock are ...

The role of circadian gene CLOCK in cancer - PubMed

Therefore, abnormal expression of CLOCK affects its role in the circadian clock and its more general function as a direct regulator of gene expression. This ...

The role of circadian clocks in cancer: Mechanisms and clinical ...

Circadian genes mediate the interplay between tumor cells and the TME through regulation of downstream CCGs, which are involved in cell cycle, apoptosis, DNA- ...

The role of circadian gene CLOCK in cancer - ScienceDirect.com

CLOCK regulates the proliferation, invasion, and drug resistance of cancer cells, and remodeling of immunosuppressive TME.

Cancer and the Circadian Clock - AACR Journals

The circadian clock is an evolutionarily conserved, molecular time-keeping mechanism that regulates daily oscillations of biological processes and behaviors (1– ...

Learning from circadian rhythm to transform cancer prevention ...

Chronic circadian rhythm disruption (CRD) increases the risk for, and severity of, cancer. · The circadian system regulates multiple cancer ...

Circadian clock: a regulator of the immunity in cancer

Circadian clock components can modulate cancer antigen-specific T cells and NK cells to kill cancer cells. Immune escape is generally a negative ...

Molecular crosstalk between circadian clock and cancer ... - Frontiers

The circadian clock machinery is reprogrammed by oncogenic pathways and chromatin remodeling in cancer tissues, thereby gaining fundamental functions in cancer ...

The Relationship between Circadian Rhythm and Cancer Disease

Clock-regulated genes express themselves rhythmically, coordinating cellular functions with the daily cycle of light and dark to maximize physiological ...

Clock genes and cancer development in particular in endocrine ...

In particular, clock genes may affect cancer susceptibility regulating nucleotide excision repair, DNA damage checkpoints and apoptosis (Sahar et al. 2009, ...

The role of circadian clock genes in leukemia - Yang

Studies of animal models (15) and human cancers have established that disrupted circadian rhythm is an essential endogenous factor contributing to cancer ...

Circadian rhythm regulates the function of immune cells ... - Nature

... clock genes and cancer-related genes, and affect many metabolic pathways and factors, thereby affecting the function of the immune system ...

Circadian regulator BMAL1::CLOCK promotes cell proliferation in ...

Our findings establish anti-apoptotic roles of the master clock regulators BMAL1 and CLOCK in promoting proliferation of liver cancer cells and ...

Role of Clock Genes and Circadian Rhythm in Renal Cell Carcinoma

Circadian rhythm regulates cellular differentiation and physiology and shapes the immune response. Altered expression of clock genes might lead to the onset ...

Circadian rhythms and breast cancer: unraveling the biological ...

produce an “accelerated aging” phenotype, suggesting that central and peripheral molecular clocks play an important role in aging (64).

The role of circadian clock genes in tumors | OTT - Dove Medical Press

At the molecular level, the circadian clock system is mainly composed of multiple positive and negative transcription–translation autoregulatory ...

Full article: The role of circadian clock genes in tumors

The Clock gene knockdown upregulates the transcript levels of p53, p21, Chk1, and Chk2 and changes the rhythmic profile of Wee1. ... Moreover, the Clock gene has ...

Enhancing circadian clock function in cancer cells inhibits tumor ...

We found that clock genes were suppressed in B16 cells and tumors, but treatments inducing circadian rhythmicity, such as dexamethasone, ...

Clocks, cancer, and chronochemotherapy - Science

The circadian clock coordinates daily rhythmicity of biochemical, physiologic, and behavioral functions in humans. Gene expression, cell ...