The role of lipid rafts in T cell antigen receptor

The role of lipid rafts in T cell antigen receptor (TCR) signalling

Plasma membranes of many cell types contain domains enriched in specific lipids and cholesterol, called lipid rafts. In T lymphocytes, key T cell antigen ...

The role of lipid rafts in T cell antigen receptor (TCR) signalling

The data suggest that lipid rafts are important in controlling appropriate protein interactions in resting and activated T cells.

Lipid rafts in T cell receptor signalling (Review) - PMC

In T cells, molecules with a key role in TCR signalling, including Lck, localize to these domains. Importantly, mutant versions of these proteins which fail to ...

The role of lipid rafts in T cell antigen receptor (TCR) signalling

Plasma membranes of many cell types contain domains enriched in specific lipids and cholesterol, called lipid rafts. (. ) In T lymphocytes, key T cell ...

Transcriptional Regulation of T-Cell Lipid Metabolism - Frontiers

TCR signaling: when T-cell receptors (TCRs) become antigen stimulated they associate with lipid rafts, plasma membrane microdomains enriched in ...

T‐cell antigen receptor triggering and lipid rafts - EMBO Press

T‐cell antigen receptor triggering mechanisms and lipid rafts are of broad interest, but are also controversial topics.

Aggregation of Lipid Rafts Accompanies Signaling via the T Cell ...

The role of lipid rafts in T cell antigen receptor (TCR) signaling was investigated using fluorescence microscopy. Lipid rafts labeled with cholera toxin B.

The role of lipid rafts in signalling and membrane trafficking in T ...

As in epithelial cells, rafts are used also as vesicular carriers for membrane trafficking in T lymphocytes. Furthermore, there are potential ...

The T cell receptor resides in ordered plasma membrane ... - Nature

Two related models for T cell signalling initiation suggest either that T cell receptor (TCR) engagement leads to its recruitment to ordered ...

Lipid rafts: cell surface platforms for T cell signaling - SciELO Chile

Thus rafts are hotspots for both protein and lipid signalling pathways. Key terms: lipid rafts; Lck; tyrosine kinase; T cell; signalling; phosphatase. (*) ...

Lipid raft-based membrane order is important for antigen-specific ...

Lipid rafts are cholesterol and saturated lipid-rich, nanometer sized membrane domains that are hypothesized to play an important role in ...

The role of lipid rafts in T cell antigen receptor (TCR) signaling

Plasma membranes of many cell types contain domains enriched in specific lipids and cholesterol, called lipid rafts. In T lymphocytes, key T cell antigen ...

Visualizing Lipid Raft Dynamics and Early Signaling Events during ...

Recent biochemical evidence indicates that an early event in signal transduction by the B-cell antigen receptor (BCR) is its translocation ...

ROLE OF LIPID RAFT-BASED MEMBRANE ORDER IN SIGNALING ...

ROLE OF LIPID RAFT-BASED MEMBRANE ORDER IN SIGNALING THROUGH THE ANTIGEN RECEPTOR IN CD4+ T CELLS: INVESTIGATING THE MECHANISM · Split-Screen ...

T‐cell antigen receptor triggering and lipid rafts - EMBO Press

T‐cell antigen receptor triggering mechanisms and lipid rafts are of broad interest, but are also controversial topics. Here, we review some recent progress ...

Lipid rafts in immune signalling: current progress and future ...

Various receptors present on immune cells like B cells, T cells, basophils and mast cells associate with lipid rafts on ligand binding and ...

Direct Regulation of the T Cell Antigen Receptor's Activity ... - Frontiers

In this review, we focus on the role of plasma membrane cholesterol, which directly binds to the αβ T cell antigen receptor (TCR), and has at least two ...

Lipid rafts and T‐lymphocyte function: Implications for autoimmunity

A structural feature that supports membrane segmentation implicates assemblies of selected lipids broadly referred to as lipid rafts. In T- ...

The role of lipid rafts in T cell antigen receptor (TCR) signalling - Scite

“…The T-cell receptor is a wellstudied example for this. 38 Stimulation of T-cell receptor by antigen-presenting cells triggers its oligomerization. This ...

Cutting Edge: Lipid Raft Integrity Affects the Efficiency of MHC Class ...

We further provide evidence that TCR interact (associate) with lipid raft elements on the T cell surface before receptor engagement and that the topological ...