The role of telomeres and telomerase in the senescence of ...

The role of telomeres and telomerase in the senescence ... - PubMed

Telomerase subunits in post-mitotic cells translocate between the nucleus, cytoplasm and mitochondria, participating in the regulation of their ...

Telomerase subunits regulate senescence of cells through limiting of ROS production which prevents telomere dysfunction.

Senescence and immortalization: role of telomeres and telomerase

Telomere dynamics are a critical component of both aging and cancer. Telomeres progressively shorten in almost all dividing cells and most human cells do ...

Roles of telomeres and telomerase in cancer, and advances in ...

Telomeres, repetitive (TTAGGG) DNA–protein complexes at the ends of chromosomes, are crucial for the survival of cancer cells. They are ...

Senescence and immortalization: role of telomeres and telomerase

Telomere dynamics are a critical component of both aging and cancer. Telomeres progressively shorten in almost all dividing cells.

The Role of Telomeres and Telomerase - Sage Journals

Expression of telomerase stabilizes telomere length and allows for continual replication, or cell immortality. This article reviews recent evidences for the ...

Cell Process: What role do the telomeres play in senescence?

However, with aging and in certain cell types where telomerase activity is low, replicative senescence ensues. Many types of cancer cells exhibit unrestricted ...

Telomeres and cell senescence (video) | Khan Academy

A mutation in the HeLa cells causes them to express telomerase, which is not normal for somatic cells. Through repeated cell divisions, the ...

Role of Telomeres and Telomerase in Aging and Cancer

A hallmark of advanced malignancies is the ability for continuous cell divisions that almost universally correlates with the stabilization of telomere length by ...

Telomere dysfunction in ageing and age-related diseases - Nature

Telomere shortening and damage are recognized causes of cellular senescence and ageing. Several human conditions associated with normal ageing are precipitated ...

Telomeres and Telomerase in Cellular Aging (Senescence)

As cells replicate, telomeres shorten at the end of chromosomes, and this process correlates to senescence or cellular aging. Integral to this ...

Role of Telomerase in Cell Senescence and Oncogenesis

To proliferate beyond the senescent checkpoint, cells must restore telomere length. This can be achieved by telomerase, an enzyme with reverse- ...

Role of telomeres and telomerase in genomic instability ...

Dysfunctional telomeres activate p53 to initiate cellular senescence or apoptosis to suppress tumorigenesis. However, in the absence of p53, telomere ...

Review The role of telomeres and telomerase in stem cell aging

Telomeres and telomerase are main components of the stem cell “ignition” mechanism, providing a way to restrain cancer and delay aging.

Role of telomeres and telomerase in genomic instability ... - Nature

Loss of telomere function results from either alteration in the capping function at telomeres, or from progressive loss of telomeric repeats ...

The role of telomeres and telomerase in the senescence of ...

Telomeres are ribonucleoprotein structures that protect the end of linear chromosomes from recognition as DNA double-stranded breaks and activation of a DNA ...

Telomeres and senescence: The history, the experiment, the future

Telomere length has been proposed to signal entry into cellular senescence. Expression of the human telomerase subunit, hTERT, in primary cells now shows that ...

Unlocking longevity: the role of telomeres and its targeting ... - Frontiers

Telomere dysfunction intensifies the molecular hallmarks of aging, potentially amplifying age-related diseases like neurodegeneration and cancer; conversely, ...

telomere shortening, cell senescence and mitochondria dysfunction

The main function of telomeres is to protect chromosome ends from being recognized as double-strand DNA damage through recruitment of shelterin, ...

Are Telomeres the Key to Aging and Cancer - Learn Genetics (Utah)

An enzyme named telomerase adds bases to the ends of telomeres. In young cells, telomerase keeps telomeres from wearing down too much. But as cells divide ...