The toxic Aβ oligomer and Alzheimer's disease

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need ...

The 'toxic Aβ oligomer' hypothesis has attracted considerable attention among Alzheimer's disease researchers as a way of resolving the lack ...

Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment ...

The fibrils catalyze a secondary nucleation reaction which gives rise to the toxic AβOs. Formation of toxic AβOs from monomers through a fibril-catalyzed ...

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need ...

This review article discusses the basis of β-amyloid's contribution to Alzheimer's disease pathology and critically examines the toxic Aβ oligomer ...

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need ...

The 'toxic Aβ oligomer' hypothesis has attracted considerable attention among Alzheimer's disease researchers as a way of resolving the lack of correlation ...

Early diagnosis and treatment of Alzheimer's disease by targeting ...

Transient soluble oligomers of amyloid-β (Aβ) are toxic and accumulate early prior to insoluble plaque formation and cognitive impairment in Alzheimer's ...

Neurotoxic Soluble Amyloid Oligomers Drive Alzheimer's ...

... Aβ) oligomers as upstream pathogenic drivers of Alzheimer's disease (AD) ... The four antibodies partially engage and inhibit the toxicity of Aβ oligomers ...

Amyloid β-protein oligomers and Alzheimer's disease

The neurotoxic effects of synthetic Aβ oligomers ... Benilova I, Karran E, Strooper BD: The toxic Aβ oligomer and Alzheimer's disease: an emperor ...

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and ...

The recent shift in the Aβ cascade hypothesis from all Aβ to small soluble oligomeric intermediates is directing the search for therapeutics towards the toxic ...

Early onset diagnosis in Alzheimer's disease patients via amyloid-β ...

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes. ... Highly specific detection of Aβ oligomers in early Alzheimer's ...

Aβ toxicity in Alzheimer's disease: globular oligomers (ADDLs) as ...

1, right panel). The toxic preparations contain exclusively small globular proteins, which we have named ADDLs, for “Aβ-derived diffusible ligands.”.

Toxic oligomer species of amyloid-β in Alzheimer's disease, a timing ...

To my knowledge, very little is known about the toxicity of Aβ oligomers purified from brain tissue. ... The toxic Abeta oligomer and Alzheimer's disease: an ...

The Toxicity and Polymorphism of β-Amyloid Oligomers - MDPI

The toxicity of Aβ trimers is currently controversial. It was found that trimers and tetramers prepared by PICUP aggregation had prominent toxicity to neurons, ...

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need ...

The 'toxic Aβ oligomer' hypothesis has attracted considerable attention among Alzheimer's disease ... The toxic Aβ oligomer and Alzheimer's disease: an emperor in ...

Structure–neurotoxicity relationships of amyloid β-protein oligomers

To address the question of oligomer-specific toxic activity, we calculated the toxicity of each oligomer relative to monomer (relative toxicity; Table S2).

The biogenesis and biology of amyloid β oligomers in the brain

In humans, as in mice, a toxic halo defined by the presence of dystrophic neurites extends from the outer surface of Thioflavin S plaque cores.

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer's disease

Consistent with this hypothesis, mitochondrial impairment caused by oligomeric Aβ or toxic ... Aβ to mitochondrial toxicity in Alzheimer's disease ...

Cellular Prion Protein Mediates the Toxicity of β-Amyloid Oligomers

... Aβ peptides that, in turn, assemble into toxic Aβ oligomers. β-Amyloid ... the Toxicity of β-Amyloid Oligomers: Implications for Alzheimer Disease.

Towards an understanding of amyloid-β oligomers - RSC Publishing

Alzheimer's disease (AD) is characterized by an imbalance between ... Aβ species, structured oligomers are proposed to be more toxic t.

Amyloid oligomers: formation and toxicity of Aβ ... - FEBS Press

The high toxicity of low-MW Aβ oligomers is also supported by in vitro studies showing that Aβ dimers are threefold more toxic than monomers, ...

A Sensitive Aβ Oligomer Assay Discriminates Alzheimer's and Aged ...

(2012) The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes. ... Alzheimer's disease patients. J Alzheimers Dis 31 ...