The transfer of multigene panel testing for hereditary breast and ...

Until recently, the molecular diagnosis of hereditary breast and ovarian cancer (HBOC) was mostly based on BRCA1/2 testing.

In conclusion, multigene panel testing is a powerful tool to identifying high to low-risk HBOC susceptibility genes. The penetrance and spectrum of cancers with ...

The transfer of multigene panel testing for hereditary breast and ...

The advent of next generation sequencing technologies and the recent discovery of new genes involved in HBOC progressively permitted the transfer of genomic ...

The transfer of multigene panel testing for hereditary breast and ...

The transfer of multigene panel testing for hereditary breast and ovarian cancer to healthcare: What are the implications for the management ...

Multigene Panel Testing for Breast and Ovarian Cancer Risk ...

Importance The practice of genetic testing for hereditary breast and/or ovarian cancer (HBOC) is rapidly evolving owing to the recent ...

Multigene panel testing for hereditary breast and ovarian cancer in ...

The aim of this study was to determine the diagnostic yield of multigene panel testing among patients referred with hereditary breast and ovarian cancer (HBOC).

About the Multi-Gene Panel Test for Hereditary Breast and Ovarian ...

This multi-gene panel test is done to check your DNA for gene mutations linked to hereditary breast and ovarian cancer.

Next step in molecular genetics of hereditary breast/ovarian cancer

The present study pretends to evaluate the clinical utility of the use of a multigene panel in patients with HBOC and a previous non-informative test for BRCA1 ...

BRCA gene test for breast and ovarian cancer risk - Mayo Clinic

A multigene panel test looks for changes in many different genes. It can be used to look for changes in the BRCA genes and other genes that ...

Multi-Gene Panel Testing of 23179 Individuals for Hereditary Cancer ...

Furthermore, multi-gene panels increase the likelihood of detecting an underlying germline genetic component in diseases with genetic heterogeneity, such as ...

Clinical usefulness of NGS multi-gene panel testing in hereditary ...

The use of multi-gene hereditary cancer panels increases the possibility to identify individuals with cancer predisposing gene variants. Our ...

Initial Results of Multigene Panel Testing for Hereditary Breast and ...

Multigene panel testing for hereditary cancer risk has recently become commercially available; however, the impact of its use on patient care is undefined.

Consensus Guideline on Genetic Testing for Hereditary Breast Cancer

It is also reasonable to order a multi-gene panel if the family history is incomplete. (i.e., a case of adoption, patient is uncertain of exact ...

A Systematic Comparison of Traditional and Multigene Panel ...

The specific type and scope of testing varied (Supplemental Table S2). HBOC, hereditary breast/ovarian cancer; NCCN, National Comprehensive ...

Panel Testing for Familial Breast Cancer: Calibrating the Tension ...

Gene panel sequencing is revolutionizing germline risk assessment for hereditary breast cancer. Despite scant evidence supporting the role ...

Should multi-gene panel testing replace limited BRCA1/2 testing? A ...

At the same time, panel testing comes with limitations; most notably a lack of clear management guidelines for mutations in moderate penetrance genes and ...

Psychological and health behaviour outcomes following multi-gene ...

Genetic testing for HBOC risk now involves multi-gene panel testing, which includes well characterized high-penetrance genes (e.g. BRCA1 and ...

Multigene panel testing results for hereditary breast cancer in 1325 ...

The application of the Next Generation Sequencing (NGS) technology has facilitated multigene panel testing for hereditary breast cancer (BC) in clinical ...

Clinician-Reported Impact of Germline Multigene Panel Testing on ...

Germline genetic testing for hereditary cancer predisposition syndromes provides risk stratification and allows clinicians to personalize ...

The Cost-Effectiveness of Multigene Panel Testing for Hereditary ...

Background. Expansion of routine genetic testing for hereditary breast and ovarian cancer from conventional BRCA testing to a multigene test ...