Therapeutic advances in leiomyosarcoma

Therapeutic advances in leiomyosarcoma - PMC

First-line therapy for metastatic and/or unresectable leiomyosarcoma includes anthracycline or gemcitabine based regimens, which provide a ...

Therapeutic advances in leiomyosarcoma - PubMed

The most promising approaches for advanced leiomyosarcoma include targeting DNA damage repair pathways and aberrant metabolism associated with oncogenesis.

Trabectedin and Doxorubicin Effective for Leiomyosarcoma - NCI

Treating people with advanced leiomyosarcoma with the combination of the chemotherapy drugs trabectedin (Yondelis) and doxorubicin can help them live longer, a ...

The biology and treatment of leiomyosarcomas - ScienceDirect.com

The anthracycline doxorubicin is the most commonly used first-line therapy for advanced LMS and is one of the first agents seen to produce meaningful responses ...

Novel Therapeutics in the Treatment of Uterine Sarcoma

Surgical treatment—including total abdominal hysterectomy, bilateral salpingo-oophorectomy, and metastasectomy, when feasible—is the standard ...

New strategies in soft tissue sarcoma treatment

Leveraging advanced molecular profiling, researchers are now tailoring treatments to the unique genetic makeup of tumors, with targeted ...

The Future of Targeted Therapy for Leiomyosarcoma - MDPI

This finding of synthetic lethality has led to the use of PARP inhibitors such as olaparib, rucaparib, niraparib, and talazoparib in the treatment of tumors ...

Doxorubicin–Trabectedin with Trabectedin Maintenance in ...

... treatment in patients with advanced leiomyosarcoma. Methods. We ... A Late-Arriving but Welcome Advance in Sarcoma Therapy. R.S. Benjamin ...

Leiomyosarcoma - Overview - Mayo Clinic

Treatment · Surgery. The goal of surgery is to remove all of the leiomyosarcoma. · Radiation therapy. Radiation therapy uses powerful energy beams ...

Soft Tissue Sarcoma Research - NCI

Results from a French clinical trial have identified what experts say should now be the recommended initial treatment of advanced leiomyosarcoma. In the ...

Advancements in Sarcoma Research and Treatment

We spoke with Stanford Cancer Institute member Nam Bui, MD, a clinical assistant professor of medicine and sarcoma specialist, to gain further insights.

Doxorubicin plus dacarbazine, doxorubicin plus ifosfamide, or ...

... treatment of advanced leiomyosarcoma and warrant further studies. Th...

LMS Research Updates - Leiomyoarcoma.info

Fourteen-Day Gemcitabine-Docetaxel Chemotherapy Is Effective and Safer Compared to 21-Day Regimen in Patients with Advanced Soft Tissue and Bone Sarcoma. A ...

A Late-Arriving but Welcome Advance in Sarcoma Therapy

Abstract. Advances in therapy for soft-tissue sarcomas are difficult. Sarcomas are rare, accounting for less than 2% of all cancers. Large ...

Trabectedin and low-dose radiation therapy in patients with ...

In addition, four advanced and progressing leiomyosarcoma patients, all with extraordinarily long progression-free survival of over 18 months, ...

Therapeutic advances in leiomyosarcoma - OUCI

Leiomyosarcoma is an aggressive mesenchymal malignancy and represents one of the most common subtypes of soft tissue sarcomas.

Second and later lines of therapy for metastatic soft tissue sarcoma

Outline · SUMMARY AND RECOMMENDATIONS · INTRODUCTION · ANGIOSARCOMA · Second-line therapy · LEIOMYOSARCOMA · Second-line therapy · SYNOVIAL SARCOMA.

New Targeted Drug Therapy for Advanced Sarcoma Extends ...

Learn more about olaratumab, a promising drug that has been shown to extend survival for people with advanced soft tissue sarcoma ...

Immunotherapy for Sarcoma - Cancer Research Institute

Fortunately, immune-based treatments, collectively known as immunotherapy, have helped against other advanced cancers and have begun to show benefits in certain ...

Current molecular and therapeutic advances in liposarcoma ...

In leiomyosarcoma, vascular endothelial growth factor (VEGF) and VEGFR family directed against multikinase inhibitors and anti-VEGF monclonal ...