Therapeutic applications of germline testing for cancer ...

Germline genetic testing is traditionally carried out in patients suspected with hereditary cancer syndrome for enhanced cancer surveillance ...

We evaluated the clinical utility of actionable (treatable) pathogenic germline mutations (PGM) in a tertiary cancer center in Asia.

Therapeutic applications of germline testing for cancer ... - PubMed

One-third of cancer patients tested carried a PGV and ∼80% were clinically actionable. Three-quarters of germline-positive advanced cancer ...

Few People with Cancer Undergo Germline Testing - NCI

These tests use blood samples to look for changes in specific cancer-related genes inherited from a parent. Like biomarker tests, germline ...

Germline Genetic Testing After Cancer Diagnosis - JAMA Network

Genetic testing can also improve outcomes for relatives of patients with cancer by modifying cancer screening and preventive therapies. Germline ...

Therapeutic Implications of Germline Testing in Patients With ...

Tumor mutational profiling is increasingly performed in patients with advanced cancer. We determined the extent to which germline mutation ...

Indications for germline testing in cancer patients

The germline test assesses a blood sample for variants associated with hereditary cancer risk. 2. Personal and family history. Patients who have a personal or ...

(PDF) Therapeutic applications of germline testing for cancer ...

Conclusions One-third of cancer patients tested carried a PGV and ∼80% were clinically actionable. Three-quarters of germline-positive advanced cancer patients ...

Paired Tumor-Germline Testing as a Driver in Better Cancer Care

Paired tumor-germline testing improves understanding of both genomes. Tumor findings can elucidate germline variants. The detection of a P/LP or ...

The Impact of Germline Testing for Hereditary Cancer Postdiagnosis

In addition to guiding optimal surgical and therapeutic decisions, germline testing identifies patients for whom there may be contraindications.

Germline Mutations and Their Clinical Applications in Cancer

Altogether, our results suggest that germline genomes, biomarkers or even TIME profile could be used in either cancer prognosis or diagnosis. Unlike gene ...

Testing to identify genomic variants related to cancer

Paired somatic-germline testing uses results from germline testing to help identify variants unique to cancer cells. In this test approach, germline testing ...

Therapeutic applications of germline testing for cancer ...

Request PDF | Therapeutic applications of germline testing for cancer predisposition genes in Asia in the real world.

Points to consider for reporting of germline variation in patients ...

Germline findings from tumor testing may be unexpected since many individuals harboring clinically actionable germline variants do not meet clinical guidelines ...

Germline testing and genetic counselling in prostate cancer - Nature

Medical or clinical genetic testing is a comprehensive process that involves extensive interrogation of multiple genes or genetic regions to ...

Germline Testing in Prostate Cancer: When and Who to Test

Germline testing in prostate cancer may inform treatment decisions and consideration for clinical trials. There are 2 FDA approved PARP ...

Germline testing may benefit all patients with metastatic, recurrent ...

... cancer had a germline alteration with therapeutic actionability ... Multigene germline genetic testing should be considered for all patients with ...

Genetic Testing Fact Sheet - National Cancer Institute

Tumor genetic testing, which may also be referred to as tumor DNA sequencing, somatic testing, or biomarker testing, looks for genetic changes ...

Next-Generation Tumor Genetic Testing

A tumor genetic profiling test is often called “genomic testing” or “molecular profiling.” The test uses a sample from your tumor, your blood, or both. The ...

Identifying germline mutations associated with cancer risk ... - Illumina

Whole-genome sequencing provides a comprehensive picture of germline mutations across the entire cancer genome. Targeted sequencing studies use hereditary ...