Therapeutic potential of targeting telomeric proteins and DNA repair ...

Shelterin proteins regulate genomic stability by preventing inappropriate DNA damage responses (DDRs) at telomeres. Unprotected telomeres lead to persistent ...

Shaping DNA damage responses: Therapeutic potential of targeting ...

Structural changes to DNA alter the DNA damage response and reduce the protection role of shelterin proteins at telomeric repeats [7]. Therefore, targeting the ...

Novel therapeutic strategies targeting telomere maintenance ... - NCBI

Telomerase, a functional ribonucleoprotein enzyme complex, maintains telomere length by adding telomeric DNA repeats at the 3′ ends of linear ...

A telomere-targeting drug depletes cancer initiating cells ... - Nature

Proteomic profiling studies identified upregulation of DNA repair proteins such as poly-ADP ribose polymerase (PARP1), enhancer of Zeste Homolog ...

Therapeutic potential of targeting telomeric proteins and DNA repair ...

Shaping DNA damage responses: Therapeutic potential of targeting telomeric proteins and DNA repair factors in cancer. https://doi.org/10.1016/j.coph ...

Combining old and new concepts in targeting telomerase for cancer ...

ROS directly damages telomeric DNA by inducing oxidative modifications, including DNA strand breaks and base modifications. Telomeres are ...

Telomere-driven diseases and telomere-targeting therapies

In addition, mutations in telomere length maintenance genes and in shelterin components, the protein complex that protects telomeres, have been found to be ...

Shelterin protein complexes are involved in distinguishing telomere ends from damaged DNA and can induce DDR. The TRF2 and POT1 proteins suppress ATM- and ATR- ...

Telomerase-targeted therapies in myeloid malignancies

In summary, shelterin subunits function together to protect the structure of telomere DNA and prevent inappropriate DNA damage responses. Loss ...

Therapeutic Targeting of Telomerase - MDPI

Telomere length and cell function can be preserved by the human reverse transcriptase telomerase (hTERT), which synthesizes the new telomeric DNA from a RNA ...

The End Game: Targeting Telomere Processing in Cancer

For solid tumors, researchers are exploring the potential of therapeutic DNA vaccines. These vaccines deliver DNA that encodes a modified ...

Targeting Telomere Dynamics as an Effective Approach for the ...

The shelterin plays an important role in avoiding telomere from being recognized as DNA damage sites, recruiting telomerase to telomere ends, ...

The Molecular Mechanisms and Therapeutic Prospects of ... - MDPI

The chromosome ends are further shortened by telomere end-processing to form 3′-overhangs. Exposed double-stranded telomere ends trigger DNA damage repair (DDR) ...

Telomeres are favoured targets of a persistent DNA damage ...

Overexpression of hTERT, the catalytic subunit of telomerase, has been shown to counteract telomere shortening, extend the replicative potential ...

Systematic Analysis of Compounds Specifically Targeting ...

The targeting of telomerase and telomere maintenance mechanisms represents a promising therapeutic approach for various types of cancer.

Novel therapeutic strategies targeting telomere maintenance ...

In ALT cancer cells PML bodies specifically co-localise to telomeric DNA, and are thought to facilitate HR [14, 26]. ALT associated PML bodies ...

TRF1 and TRF2: pioneering targets in telomere-based cancer therapy

These proteins, integral to the shelterin complex, interact with various telomeric proteins and play essential roles in the DNA damage response, ...

Targeted DNA damage at individual telomeres disrupts their integrity ...

KillerRed (KR) is a unique fluorescent protein capable of generating site-specific ROS upon visible light illumination (550–580 nm) (12–14). We ...

potential treatment target, particularly for DDR-related molecules. ... inhibit the growth of ALT-positive cancer cells (Moglan et al., 2023).

Telomere Targeting Chimera Enables Targeted Destruction of ...

Therefore, telomeres are regarded as a potential anticancer target. In this study, we report the development of a nucleotide-based proteolysis- ...