Three studies highlight how proteins are altered in multiple cancer ...

The team found key modifications, such as the phosphorylation and acetylation of key proteins, that are associated with various biochemical ...

Broad Institute of MIT and Harvard's Post - LinkedIn

In three new pan-cancer studies, researchers including Yifat Geffen, Gaddy Getz, & members of Broad's Proteomics Platform have harmonized ...

#WhyIScience Q&A: A biochemist uses mass spectrometry to find ...

The magnifying glass · News 08.14.2023 · Three studies highlight how proteins are altered in multiple cancer types · Read more · Protein changes ...

Scientists reveal how proteins drive growth of multiple cancer types

“Through our past work sequencing the genomes of cancer cells, we identified almost 300 genes driving cancer. Now, we are studying the details ...

Altered expression of proteins in cancer: function and potential ...

The disrupted metabolism of cancer cells (1) and immune cells of the TME (2) is controlled by several protein families. As such, it is not ...

Editorial: Altered Expression of Proteins in Cancer - PubMed Central

Cancer cells show extensive alterations in protein expression levels, which are drivers of their malignant transformation. Proteins with altered ...

The regulation of protein translation and its implications for cancer

... proteins plays an important role in the pathogenesis of various cancers ... Taken together, these studies highlight the balance between RBPs and ...

Pan-cancer analysis of post-translational modifications reveals ...

... altered in multiple cancers to both expand and complement genomic studies. To this end, we generated a harmonized pan-cancer cohort using ...

Proteins in blood could give cancer warning seven years earlier

Both studies, published today in Nature Communications, used a powerful technique called proteomics to find important differences in blood ...

Cancer Mutations Converge on a Collection of Protein Assemblies ...

Rapid proliferation is a hallmark of cancer associated with sensitivity to therapeutics that cause DNA replication stress (RS). Many tumors exhibit drug ...

Protein palmitoylation and cancer | EMBO reports

Hallmark cancer cell phenotypes such as sustained proliferation, resistance to cell death, and increased metastasis result from the altered activity of ...

Systematic characterization of mutations altering protein ...

From the start of DNA sequencing studies of human tumors (Barbieri et al., 2012; Cancer Genome Atlas Research Network, 2008; Jones et al., 2008; ...

Identifying proteomic risk factors for cancer using prospective and ...

3). Among the proteins associated with risk of haematological cancers, we identified associations with risk of multiple blood cancers for ...

Altered glycosylation of several metastasis-associated glycoproteins ...

Several distinct metastasis-associated glycosylation changes have been shown to promote cancer cell invasion and metastasis, the main cause of ...

Post-translational Modifications (PTMs), from a Cancer Perspective

Manifestation of cancer is complex and involves multiple steps including modifications at the levels of genes, associated proteins and signaling pathways.

Studies Delve Deep into the Protein Machinery of Cancer Cells - NCI

Another of the UCSF/UCSD studies focused on identifying protein–protein interactions in breast cancer, while the third study combined findings ...

Predicting the functional impact of protein mutations - Oxford Academic

Mutations have an effect on cancer as a tissue in an organism in the complicated context of the typically numerous alteration in a given tumor ( ...

Pan-cancer proteogenomics expands the landscape of ... - Cell Press

Integration of proteomic data from tumors and genetic screen data from cell lines identifies protein overexpression- or hyperactivation-driven druggable ...

Visualization of breast cancer-related protein synthesis from the ...

When breast cancer cells overexpress these hormones or their receptors, they can become more aggressive and resistant to treatment [17,18,19,20] ...

Altered Expression of Proteins in Cancer: Function and Potential ...

... proteins and several have been identified as targets for cancer ther ... The major goal of this Research Topic is to highlight the relevance of ...