Tissue|specific impacts of aging and genetics on gene expression ...

Tissue-specific impacts of aging and genetics on gene expression ...

Here, we quantify the relative contributions of genetics and aging to gene expression patterns across 27 tissues from 948 humans.

Tissue-specific impacts of aging and genetics on gene expression ...

Together we present a novel framework for predicting gene expression phenotypes from genetics and age and provide insights into the tissue- ...

Tissue-specific impacts of aging and genetics on gene expression ...

02 are shown. C) Average gene expression variance explained by age for mitochondrial (MT) genes (red), translation factor genes (purple), interferon gamma ...

Tissue-specific impacts of aging and genetics on gene expression ...

These non-Medawarian tissues exhibit high rates of cancer and age-of-expression-associated somatic mutations. In contrast, genes under genetic ...

(PDF) Tissue-specific impacts of aging and genetics on gene ...

These non-Medawarian tissues exhibit high rates of cancer and age-of-expression-associated somatic mutations. In contrast, genes under genetic control are under ...

Tissue-specific impacts of aging and genetics on gene expression ...

These non-Medawarian tissues exhibit high rates of cancer and age-of-expression-associated somatic mutations. In contrast, genes under genetic control are under ...

Global and tissue-specific aging effects on murine proteomes

Our findings confirm that the discordance between age-related changes in proteins and gene expression occurs across multiple tissues. Our data ...

Age plays a more important role than genetics in affecting gene ...

In a study of the relative effects of genetics, aging and the environment on how some 20,000 human genes are expressed, the researchers found ...

Inter-tissue convergence of gene expression during ageing ... - eLife

Developmental trajectories of gene expression may reverse in their direction during ageing, a phenomenon previously linked to cellular identity loss.

Synchronized age-related gene expression changes across multiple ...

The total cholesterol associated genes and obesity-related traits are significantly over-represented in the adipose tissue down-regulated aging ...

Tissue-specific impacts of aging and genetics on gene expression ...

We show that gene expression patterns become more erratic with age in several different tissues reducing the predictive power of expression quantitative trait ...

Genetic regulation of gene expression and splicing during a 10-year ...

Prior cross-sectional studies have investigated the combined effects of age and genetics on gene expression and alternative splicing; however, ...

Time is ticking faster for long genes in aging: Trends in Genetics

Transcript expression decreases with gene length in aging in humans and multiple animals. We introduce the terminology gene length-dependent ...

Age-dependent changes in mean and variance of gene expression ...

We discovered that 36.6% of tested genes (5631 of 15 353) had at least one exon where expression was significantly associated with age in at least one tissue ( ...

voyAGEr: free web interface for the analysis of age-related gene ...

By considering the percentage of genes altered in each age range, we can highlight age periods of major tissue-specific transcriptomic ...

Transcriptomic analysis reveals a tissue-specific loss of identity ...

Understanding changes in cell identity in cancer and ageing is of great importance. In this work, we analyzed how gene expression changes in ...

Tissue-specific impacts of aging and genetics on gene expression ...

Here, we set out to quantify the relative contributions of genetics and aging to gene expression patterns from data collected across 27 tissues from 948 humans.

Age or lifestyle-induced accumulation of genotoxicity is associated ...

A number of genes change their expression in the same direction during aging in several tissues, and the search for differentially expressed ...

Age vs. genetics: Which is more important for how you age?

In a study of the relative effects of genetics, aging and the environment on how some 20,000 human genes are expressed, the researchers found ...

Aging Science News on X: "Tissue-specific impacts of aging and ...

Tissue-specific impacts of aging and genetics on gene expression patterns in humans https://t.co/JbfDvXC1kp.