Towards an understanding of amyloid|β oligomers

Towards an understanding of amyloid-β oligomers - RSC Publishing

Alzheimer's disease (AD) is characterized by an imbalance between production and clearance of amyloid-β (Aβ) species.

Towards an understanding of amyloid-β oligomers - PubMed

Alzheimer's disease (AD) is characterized by an imbalance between production and clearance of amyloid-β (Aβ) species.

Towards an understanding of amyloid-β oligomers - RSC Publishing

In this review, we summarize the recent understanding of Aβ oligomers' assembly, structural properties, and toxicity, along with inhibitors against Aβ ...

Towards an understanding of amyloid-β oligomers: characterization ...

Alzheimer's disease (AD) is characterized by an imbalance between production and clearance of amyloid-β (Aβ) species. Aβ peptides can transform structurally ...

Towards an understanding of amyloid-β oligomers - ResearchGate

Aβ peptides can transform structurally from monomers into β-stranded fibrils via multiple oligomeric states. Among the various Aβ species, ...

Towards an understanding of amyloid-β oligomers - Semantic Scholar

There is growing consensus that control of toxic Aβ oligomers could be a valid approach to regulate Aβ-associated toxicity, which could advance development ...

Amyloid β-protein oligomers and Alzheimer's disease

These early findings in animal models are consistent with recent findings that human brain contains Aβ oligomers up to two decades prior to ...

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and ...

The recent shift in the Aβ cascade hypothesis from all Aβ to small soluble oligomeric intermediates is directing the search for therapeutics towards the toxic ...

Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment ...

Toxic AβOs accumulate in AD brain and constitute long-lived alternatives to the disease-defining Aβ fibrils deposited in amyloid plaques. Key experiments using ...

Liquid–liquid phase separation of amyloid-β oligomers modulates ...

In this study, we reported that AβOs can undergo liquid–liquid phase separation (LLPS) to form liquid-like droplets in vitro.

The biogenesis and biology of amyloid β oligomers in the brain

Adding fibrils to monomers increased the production of Aβ oligomers by ≈ 20-fold, convincingly demonstrating that the fibrils catalyzed a ...

Structure–neurotoxicity relationships of amyloid β-protein oligomers

The most potent neurotoxic assemblies appear to be oligomeric, rather than fibrillar, in nature (3, 4). For example, oligomers extracted from AD brain potently ...

Oligomeric amyloid-β induces early and widespread changes to the ...

Oligomeric forms of these proteins are believed to be most relevant to disease progression, with oligomeric amyloid-β (oAβ) particularly ...

Amyloid β Dodecamer Disrupts the Neuronal Membrane More ...

However, recent experiments have shown that Aβ oligomers are more toxic to neurons than highly ordered fibrils. The molecular mechanism ...

Early onset diagnosis in Alzheimer's disease patients via amyloid-β ...

According to the amyloid cascade hypothesis, amyloid-β (Aβ)-species (e.g., monomers, oligomers, fibrils, and plaques) are major hallmarks of AD ...

Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain ...

Insoluble amyloid plaques likely sequester soluble HMW oligomers, limiting their potential to dissociate. We conclude that conditions that ...

Amyloid-β Oligomers: Multiple Moving Targets - MDPI

Here, we describe a variety of biophysical techniques used to isolate and characterize a range of Aβ oligomer populations, as well as discuss ...

Towards an understanding of amyloid-β oligomers

, Towards an understanding of amyloid-β oligomers: characterization, toxicity mechanisms, and inhibitors. ;; Chemical Society (Great Britain) ;, ISSN: 0306-0012 ...

Amyloid‐β oligomers in cellular models of Alzheimer's disease

Cellular models may lead us to a deeper understanding of the detrimental effects of AβOs in neurons and glial cells, putatively shedding light ...

Conformational Differences between Two Amyloid β Oligomers of ...

Here we characterize the biochemical and structural properties of each Aβ oligomer relative to Aβ fibrils and monomers to understand the origins of their size- ...