Toxicity and assessment of chemical mixtures

Toxicity and Assessment of Chemical Mixtures

In view of recent publications dealing with risk assessment methodologies for chemical mixtures, i.e. combinations of two or more chemicals that retain their ...

Toxicity and assessment of chemical mixtures - Publications Office of ...

The EU Chemicals legislation is based predominantly on assessments carried out on individual substances. Since humans and their environments ...

Basic concepts of mixture toxicity and relevance for risk evaluation ...

The toxicity elicited by exposure to multiple substances is referred to as “mixture toxicity” (Sarigiannis and Hansen 2012; Shaw 2014). It is ...

Supplementary Guidance for Conducting Health Risk Assessment of ...

(1998) Estimation of toxicity of chemical mixtures through modeling of ... Assessment of the health impacts of single chemicals or chemical mixtures present in ...

Guidelines for Health Risk Assessment of Chemical Mixtures

Nonetheless, general guidelines can be recommended depending on the type of mixture, the known toxic effects of its components, the availability ...

Review of the toxicity of chemical mixtures: Theory, policy ... - PubMed

An analysis of current mixture theory, policy, and practice was conducted by examining standard reference texts, regulatory guidance documents, and journal ...

Retrospective Risk Assessment of Chemical Mixtures in the Big Data ...

Humans and organisms are continuously exposed to mixtures of environmental contaminants. Current risk assessments primarily focus on the ...

Regulatory assessment of chemical mixtures: Requirements, current ...

An example of such a tool is the Maximum Cumulative Ratio (MCR), which is the ratio between the toxicity of the mixture (based on CA models) and the toxicity of ...

Mixture toxicity and its modeling by quantitative structure‐activity ...

Interactions of components in a mixture can cause complex and substantial changes in the apparent properties of its constituents. The cosolutes ...

GUIDANCE MANUAL FOR CHEMICAL MIXTURES

The focus of this guidance is the exposure-based assessment of joint toxic action of chemical mixtures associated with hazardous waste sites, but suggestions ...

Statement on advancing the assessment of chemical mixtures and ...

Synergistic interactions that result in significant excess toxicity over expected additive effects are a long-standing concern of regulatory toxicology. The ...

Predictive Environmental Risk Assessment of Chemical Mixtures

Environmental risks of chemicals are still often assessed substance-by-substance, neglecting mixture effects. This may result in risk ...

Simplifying complexity: Mixture toxicity assessment in the last 20 years

Chemical monitoring provides ample evidence that organisms in their environment are exposed to complex cocktails of contaminants rather than ...

Risk assessment of environmental mixture effects - RSC Publishing

Mixture toxicity is described as synergistic if only one compound is present at a toxic level and the other components in a mixture are present ...

Regulatory assessment and risk management of chemical mixtures

Figure 1. Mapping of different types of toxicity information for individual chemicals in a mixture onto AOP networks. This mapping can help identify (1) which ...

New approaches to risk assessment of chemical mixtures

For the evaluation of a compound with unknown toxicity, it is possible to establish a “chemical bridge” to existing toxicology data of a similar ...

Assessing and regulating of chemical mixtures under REACH

In order to assess chemical mixtures using the two existing concepts (see above), data on composition, exposure and effect concentrations of the ...

MRA Toolbox v. 1.0: a web-based toolbox for predicting mixture ...

Thus, computational toxicology methods are expected to become the core technologies for conducting mixture risk assessment. Mixture toxicity ...

Public Health Guidance Values for Chemical Mixtures

When con sidered appropriate, the most toxic chemical from the mixture was selected and assumed to drive the risk assessment. The First Approach Was Designed to ...

Mixture toxicity in the Erft River: assessment of ecological risks and ...

A vast number of chemical substances are released into the aquatic environment, leading to complex chemical mixtures in surface waters.