Trabectedin and lurbinectedin

Trabectedin and lurbinectedin: Mechanisms of action, clinical impact ...

The ecteinascidins trabectedin and lurbinectedin are very interesting antineoplastic agents, with a favorable toxicity profile and peculiar ...

Effects of the Anti-Tumor Agents Trabectedin and Lurbinectedin on ...

Trabectedin and lurbinectedin share the unique feature of being able to simultaneously kill cancer cells and to affect several features of the TME, most notably ...

Trabectedin and Lurbinectedin Modulate the Interplay between ...

Trabectedin (TRB) and Lurbinectedin (LUR) are alkaloid compounds originally isolated from Ecteinascidia turbinata with proven antitumoral activity.

Immunometabolic actions of trabectedin and lurbinectedin on ...

Our results show that TRB and LUR activate human macrophages toward a pro-inflammatory phenotype by inducing a specific metabolic rewiring program.

Total Synthesis of Trabectedin, Lurbinectedin, and Renieramycin T

In this report, the total synthesis of trabectedin, lurbinectedin, and renieramycin T were accomplished in 22–27 steps.

Trabectedin - an overview | ScienceDirect Topics

Lurbinectedin (Zepzelca™) is a synthetic ecteinascidin-inspired molecule closely related to trabectedin (Yondelis®), a natural product isolated from the ...

Safety and Efficacy of the Combination Lurbinectedin plus ...

Lurbinectedin is related to trabectedin, an agent approved in Europe (second line or greater, adult patients with advanced STS) and in the ...

Specific Effects of Trabectedin and Lurbinectedin on Human ... - MDPI

2.2. Treatment of hMF with Trabectedin and Lurbinectedin Promotes Intracellular Ca2+ Rise and Changes in Mitochondrial Respiration. Incubation of hMF-R with TRB ...

Lurbinectedin reduces tumour-associated macrophages and the ...

Lurbinectedin (PM01183) is an analogue of trabectedin that has shown very promising clinical activity in a broad range of clinical trials and is ...

Comparison of in vitro and in vivo biological effects of trabectedin ...

Lurbinectedin and trabectedin had a similar pattern of antitumor activity in murine tumors and in xenografts, whereas Zalypsis® appeared to have a distinct ...

Lurbinectedin - an overview | ScienceDirect Topics

Lurbinectedin (PM01183) ... Lurbinectedin (PM01183) is a synthetic analog of trabectedin (Yondelis, ET-743), and belongs to the natural marine-based ...

Dual inhibition of ATR and ATM potentiates the activity of trabectedin ...

Lurbinectedin is a novel anticancer agent structurally related to trabectedin. Both ecteinascidins generate DNA double-strand breaks that are ...

(PDF) Trabectedin and Lurbinectedin Modulate the Interplay ...

Lurbinectedin, an analog of trabectedin, is currently approved, in various countries, as a single agent, for the treatment of patients with ...

Antitumor activity of trabectedin and lurbinectedin in germline ...

Conclusions: Remarkable activity of trabectedin and lurbinectedin as single agents was observed in BRCA 2 associated MBC. This finding warrants ...

The Antitumor Drugs Trabectedin and Lurbinectedin Induce ...

Trabectedin directly interacts with DNA, forming adducts and producing distortions of the double helix. Because R-loops impair replication ...

Trabectedin and Lurbinectedin Effective in BRCA2-Associated ...

An interim analysis of two phase 2 trials, reported in a poster session at the 2017 American Society of Clinical Oncology Annual Meeting, ...

Trabectedin and lurbinectedin: Mechanisms of action, clinical impact ...

PDF | The ecteinascidins trabectedin and lurbinectedin are very interesting antineoplastic agents, with a favorable toxicity profile and ...

Doxorubicin and Trabectedin Combination Improves Survival Among

An ongoing study of a combination of doxorubicin and lurbinectedin induction followed by lurbinectedin maintenance, as compared with ...

Trabectedin and Lurbinectedin Modulate the Interplay between ...

Keywords: trabectedin; lurbinectedin; macrophages; lymphocytes; ecteinascidins; combined thera- pies; innate immunity; adaptative immunity ...

PharmaMar will present data for ZepzelcaTM (lurbinectedin) and ...

(lurbinectedin) and Yondelis® (trabectedin) at. ESMO 2020. • Results of lurbinectedin monotherapy will be presented in patients with Small ...