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Trained Innate Immunity


Trained immunity — basic concepts and contributions to ... - Nature

Trained immunity describes the immunological process by which innate immune cells acquire immunological memory. After exposure to certain ...

Defining trained immunity and its role in health and disease - Nature

Trained immunity involves epigenetic and metabolic reprogramming of the innate immune cells, allowing qualitatively and quantitatively adjusted ...

Trained immunity: A “new” weapon in the fight against infectious ...

Trained immunity reversibly boosts the innate immune response through myeloid cells, innate lymphoid cells, stem cells, and epithelial cells, whereas ...

Trained immunity - basic concepts and contributions to ... - PubMed

Trained immunity is a functional state of the innate immune response and is characterized by long-term epigenetic reprogramming of innate immune cells.

Trained immunity - Wikipedia

Trained immunity is a long-term functional modification of cells in the innate immune system which leads to an altered response to a second unrelated ...

TRAINED INNATE IMMUNITY AND ITS IMPLICATIONS FOR ...

Trained immunity has recently emerged as a new concept that endows innate immunity with immunological memory of past inflammatory events so that the host is ...

Trained immunity: implications for vaccination - ScienceDirect.com

Trained immunity is a long-term functional reprogramming of innate immune cells following an encounter with a primary stimulus, which results in an augmented ...

Trained immunity: General and emerging concepts - Vuscan - 2024

The induction of trained innate immunity has been described in multiple innate immune cell populations, including monocytes/macrophages, ...

Trained immunity: adaptation within innate immune mechanisms

This phenomenon is termed “trained immunity” or “innate immune memory.” On one hand, trained immunity improves the response to infections and vaccination, ...

Trained innate immunity and diseases: Bane with the boon

Trained immunity can have unfavorable outcomes, such as hyper inflammation and the development of cardiovascular diseases, autoinflammatory diseases, and ...

What is Trained Immunity? - News-Medical

The ability of the innate immune system to develop adaptive features and provide long-term protection against pathogenic reinfection is termed as trained ...

Trained innate immunity, long-lasting epigenetic modulation ... - PNAS

Previously reported trained immunity inducers are, however, infrequently present in the host, whereas heme abundantly occurs during noninfectious and infectious ...

Trained immunity: A program of innate immune memory in health ...

Termed “trained immunity,” the property allows macrophages, monocytes, and natural killer cells to show enhanced responsiveness when they reencounter pathogens.

Trained Innate Immunity, Epigenetics, and Covid-19

Stimulation of innate immune cells can leave an “epigenetic scar” — a pattern of exposed enhancers and promoters of host-defense genes. Each ...

High-throughput screen identifies non inflammatory small molecule ...

Trained immunity is described as a nonspecific form of innate immune memory triggered by specific stimuli (1). It is primarily characterized by metabolic and ...

Trained Immunity Carried by Non-immune Cells - Frontiers

Trained immunity is a new concept designing the adaptative properties carried by innate immune cells such as macrophages and NK-cells. Innate ...

Trained innate immunity | Immunologic Research - SpringerLink

Researchers contend that trained immunity is influenced by intracellular metabolic pathways and epigenetic remodeling.

Training innate immunity: the changing concept of immunological ...

The lasting state of enhanced innate immunity termed 'trained immunity' is mediated by prototypical innate immune cells such as natural killer cells and ...

Trained Immunity or Tolerance: Opposing Functional Programs ...

We have termed this phenomenon “trained immunity,” defined as enhanced nonspecific innate immune protection that is suggested to be mediated by epigenetic ...

Trained innate immunity: Concept, nomenclature, and future ...

This de facto innate immune memory has been termed trained immunity. Trained immunity, which is mediated through extensive metabolic rewiring ...