Transcription|Replication Collisions and Chromosome Fragility

Transcription-Replication Collisions and Chromosome Fragility

Accurate replication of the entire genome is critical for cell division and propagation. Certain regions in the genome, such as fragile ...

Transcription-Replication Collisions and Chromosome Fragility

Accumulating evidence suggests transcription might be a major source of endogenous replication stress (RS) leading to chromosome fragility.

(PDF) Transcription-Replication Collisions and Chromosome Fragility

PDF | Accurate replication of the entire genome is critical for cell division and propagation. Certain regions in the genome, ...

Transcription-replication conflicts at chromosomal fragile sites ...

Collision between the molecular machineries responsible for transcription and replication is an important source of genome instability.

Direct visualization of transcription-replication conflicts reveals post ...

Transcription-replication collisions (TRCs) are crucial determinants of genome instability ... chromosomal breakage at DNA interstrand ...

Collisions between Replication and Transcription Complexes Cause ...

Such collisions result in CFS breakage and consequent genomic instability. ... chromosome fragility at sites of S phase transcription. Cell, 138 ...

Two mechanisms of chromosome fragility at replication-termination ...

Chromosomal fragile sites are implicated in promoting genome instability, which drives cancers and neurological diseases.

Transcription–Replication Conflicts as a Source of Genome Instability

... fragile sites genome-wide. Nat. Commun. 10 ... in G1 causes genome instability and damage signatures indicative of replication collisions.

Transcription-Replication Collisions and Chromosome Fragility - OUCI

Accurate replication of the entire genome is critical for cell division and propagation. Certain regions in the genome, such as fragile sites (common ...

New Era of Mapping and Understanding Common Fragile Sites

Early Replication Fragile Sites: where Replication-Transcription Collisions Cause Genetic Instability. ... chromosome fragility, high ...

3D genome organization contributes to genome instability at fragile ...

Common fragile sites (CFSs) are regions susceptible to replication stress and are hotspots for chromosomal instability in cancer.

Replication–Transcription Conflicts: A Perpetual War on the ...

Integrator facilitates RNAPII removal to prevent transcription-replication collisions and genome instability. ... fragile sites genome-wide ...

Transcription-Replication Collisions—A Series of Unfortunate Events

Genomic Loci Experiencing Transcription-Associated Replication Stress. 4.1. Fragile Site Instability and Oncogene Overexpression. Chromosomes contain genomic ...

where replication–transcription collisions cause genetic instability

The damaged DNA regions caused by replication stress, termed 'early replicating fragile sites' (ERFS), are characterised by their occurrence in ...

Genomic patterns of transcription–replication interactions in mouse ...

... replication timing may underlie CFS fragility ... Virtually all studies of transcription–replication collisions in mammalian cells have employed artificial DNA ...

Transcription-replication conflicts as a source of common fragile site ...

... collisions between transcription and replication ... Transcription-replication conflicts at chromosomal fragile sites-consequences in M phase and ...

Replication Stress Induces Global Chromosome Breakage in the ...

Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by mutations in the FMR1 gene and deficiency of a functional FMRP protein.

Review DNA damage and transcription stress - ScienceDirect.com

Rao, et al. Genome organization drives chromosome fragility. Cell, 170 (2017), pp. 507-521.e18.

The role of fork stalling and DNA structures in causing chromosome ...

... transcription- replication collisions as the cause of fragility at CFSs. VI. Cleavage at secondary structures within CFSs is a cause of fragility. Breakage ...

Model for head-on collision and chromosome fragility. A head-on...

Accurate replication of the entire genome is critical for cell division and propagation. Certain regions in the genome, such as fragile sites (common ...