Transcription|Replication Conflicts

Transcription–replication conflicts: how they occur and how ... - Nature

Here we review recent data on the factors and mechanisms that are involved in either preventing or resolving transcription–replication collisions, and on their ...

Consequences and Resolution of Transcription–Replication Conflicts

Upon conflict, the replisome can skip the RNAP complex by repriming downstream of it. In the case of a CD-TRC, the newly synthesized RNA can be used as a primer ...

Direct visualization of transcription-replication conflicts reveals post ...

Transcription-replication collisions (TRCs) are crucial determinants of genome instability. R-loops were linked to head-on TRCs and proposed ...

Transcription–Replication Conflicts as a Source of Genome Instability

Transcription and replication both require large macromolecular complexes to act on a DNA template, yet these machineries cannot ...

Transcription-Replication Conflicts as a Source of Genome Instability

Transcription and replication both require large macromolecular complexes to act on a DNA template, yet these machineries cannot ...

Replication–Transcription Conflicts: A Perpetual War on the ...

DNA replication and transcription occur in all living cells across all domains of life. Both essential processes occur simultaneously on the ...

Excessive transcription-replication conflicts are a vulnerability of ...

In BRCA1 deficient cells, MEPCE depletion leads to R-loop accumulation, transcription stress, and transcription-replication conflicts, which ...

Transcription-Replication Conflict Orientation Modulates R-Loop ...

Conflicts between transcription and replication are a potent source of DNA damage. Co-transcriptional. R-loops could aggravate such ...

Conflict Resolution in the Genome: How Transcription and ...

In this article, we review the cellular responses to transcription-replication conflicts and highlight how these inevitable encounters shape the genome.

Transcription-Replication Conflicts: Orientation Matters - ScienceDirect

TRCs may occur in a head-on or co-directional fashion, depending on the orientation of genes relative to the direction of fork progression.

The prevention and resolution of DNA replication–transcription ...

A failure to resolve conflicts arising between replication and transcription can lead to genome instability, as well as to the initiation of ...

Causes of transcription-replication conflicts

DNA lesion-arrested transcription complexes as source of R-loop-mediated replication stress. Bulky DNA adducts and inter-strand crosslinks can halt the ...

Transcription–replication conflicts in primordial germ cells ... - PNAS

We report that rapidly dividing mouse primordial germ cells (PGCs) are faced with high levels of endogenous replication stress due to frequent occurrence of ...

Transcription-replication conflicts as a source of common fragile site ...

Here we show that Polycomb group proteins BMI1 and RNF2 are suppressors of transcription-replication conflicts (TRCs) and CFS instability. Cells ...

DNA Replication-Transcription Conflicts Do Not Significantly ...

IMPORTANCE Because DNA replication and transcription occur on the same DNA template, encounters between the two machines occur frequently. When these encounters ...

The roles of replication-transcription conflict in mutagenesis ... - PLOS

Mutations do not arise uniformly across the genome, because multiple mechanisms for mutagenesis exist and the effect of each mechanism depends ...

Transcription–replication conflicts: how they occur and how they are ...

This work provides the current view of how transcription can generate obstacles to replication, including torsional stress and non-B DNA structures, ...

Transcription–replication conflicts: how they occur and how they are ...

Abstract. The frequent occurrence of transcription and DNA replication in cells results in many encounters, and thus conflicts, between the transcription and ...

Transcription-Replication Conflicts: Orientation Matters. - Abstract

Interference between DNA replication and transcription represents a major source of genomic instability. In this issue of Cell, Lang et al. and Hamperl et ...

Transcription–Replication Conflicts, Resolution and Coregulation

Since resolution of transcription–replication conflicts requires DNA recombination and repair, including DNA degradation and DNA synthesis by ...