- Transcription|Replication Conflicts as a Source of Genome Instability🔍
- Transcription–Replication Conflicts as a Source of Genome Instability🔍
- Transcription|replication conflicts as a source of genome instability🔍
- RAD52 resolves transcription|replication conflicts to mitigate R|loop ...🔍
- Transcription|replication conflicts as a source of common fragile site ...🔍
- Transcription|Replication Conflicts🔍
- Transcription|Replication Collisions and Chromosome Fragility🔍
- Transcription|Replication Conflict Orientation Modulates R|Loop ...🔍
Transcription|replication conflicts as a source of genome instability
Transcription-Replication Conflicts as a Source of Genome Instability
Transcription and replication both require large macromolecular complexes to act on a DNA template, yet these machineries cannot ...
Transcription–Replication Conflicts as a Source of Genome Instability
Transcription and replication both require large macromolecular complexes to act on a DNA template, yet these machineries cannot ...
Transcription-replication conflicts as a source of genome instability
This review will highlight recent studies investigating the genomic locations of TRCs and the mechanisms by which they may be prevented, mitigated or resolved.
Transcription–Replication Conflicts as a Source of Genome Instability
transcription–replication conflicts, TRCs, genomic instability, replisome,. RNA polymerase, DNA repair, origin firing, replication stress,.
RAD52 resolves transcription-replication conflicts to mitigate R-loop ...
Collisions of the transcription and replication machineries on the same DNA strand can pose a significant threat to genomic stability.
Transcription-Replication Conflicts as a Source of Genome Instability
Transcription and replication both require large macromolecular complexes to act on a DNA template, yet these machineries cannot simultaneously act on the ...
Transcription-Replication Conflicts as a Source of Genome Instability
Request PDF | Transcription-Replication Conflicts as a Source of Genome Instability | Transcription and replication both require large ...
Transcription-replication conflicts as a source of common fragile site ...
Author summary · Common fragile sites (CFSs) are natural genomic loci that are prone to gaps and breaks upon DNA replication stress. · Many CFSs harbor long genes ...
Transcription-Replication Conflicts: Orientation Matters - ScienceDirect
Interference between DNA replication and transcription represents a major source of genomic instability. In this issue of Cell, ...
Transcription-Replication Collisions and Chromosome Fragility
Although, the mechanism underlying their “difficult-to-replicate” nature and genomic instability is still not fully understood, accumulating evidence suggests ...
Transcription-Replication Conflict Orientation Modulates R-Loop ...
Conflicts between transcription and replication are a potent source of DNA damage. Co-transcriptional R-loops could aggravate such conflicts ...
The impact of transcription-mediated replication stress on genome ...
We then discuss the different mechanisms by which transcription acts as a notable source of replication stress to induce genome instability.
DNA damage and transcription stress
Conversely, the process of gene expression is itself a source of endogenous DNA lesions as a result of the susceptibility of single- stranded ...
Genomic patterns of transcription–replication interactions in mouse ...
Abstract. Conflicts between transcription and replication machinery are a potent source of replication stress and genome instability; however, no technique.
Transcription-replication conflicts as a source - ProQuest
Transcription-replication conflicts as a source of common fragile site instability caused by BMI1-RNF2 deficiency · Abstract · Full Text.
The role of chromatin at transcription-replication conflicts as a ...
The histone chaperone FACT was observed to prevent transcription-mediated genome instability, since its deficiency results in transcription-associated DNA ...
How Transcription and Replication Make It Work: Cell
With every entry into S-phase, our genomes are threatened by multiple intrinsic factors that can lead to DNA damage and genomic instability. For ...
The prevention and resolution of DNA replication–transcription ...
A failure to resolve conflicts arising between replication and transcription can lead to genome instability, as well as to the initiation of ...
Transcription–replication conflicts in primordial germ cells ... - PNAS
TRCs Impose High Levels of Endogenous Replication Stress on PGCs. TRCs are considered as a major endogenous source of genome instability, which block ...
Transcription–replication conflicts: how they occur and how they are ...
These conflicts constitute a major intrinsic source of genome instability, which is a hallmark of cancer cells. How the replication machinery progresses along a ...