Transcriptional reprogramming at the intersection of the heat shock ...

The heat shock response (HSR) is an evolutionarily well-conserved survival program that is activated in response to proteotoxic stress.

Here, we highlight the current advancements of molecular mechanisms driving transcriptional reprogramming during acute heat stress.

Transcriptional reprogramming at the intersection of the heat shock ...

Recent genome-wide approaches have delineated the molecular depth of stress-induced transcriptional reprogramming. The dramatic rewiring of gene ...

Transcriptional reprogramming at the intersection of the heat shock ...

Cellular homeostasis is constantly challenged by a myriad of extrinsic and intrinsic stressors. To mitigate the stress-induced damage, cells activate ...

Transcriptional reprogramming at the intersection of the heat shock ...

14 The rewiring of gene and enhancer networks is driven by stress-regulated transcription factors, of which heat shock factors (HSFs) have been ...

Stress-Induced Transcriptional Memory Accelerates Promoter ...

Heat shock instantly reprograms transcription. Whether gene and enhancer transcription fully recover from stress, and whether stress establishes a memory by ...

Molecular Cell on X: "Online Now: Transcriptional reprogramming at ...

Online Now: Transcriptional reprogramming at the intersection of the heat shock response and proteostasis https://t.co/KjzHjirjdN.

Transcriptional and translational dynamics underlying heat shock ...

The extensive heat shock responsive transcriptional regulation was shown to be a transient mechanism, with most transcript levels returning to ...

HSFs drive transcription of distinct genes and enhancers during ...

Abstract. Reprogramming of transcription is critical for the survival under cellular stress. Heat shock has provided an excellent model to ...

Transcriptional reprogramming at the intersection of the heat shock…

Happy to share that our review article entitled "Transcriptional reprogramming at the intersection of the heat shock response and ...

Heat stress transcription factors as the central molecular rheostat to ...

Heat stress transcription factors are in a dynamic equilibrium that shifts between active and inactive states, influenced by the environmental ...

Genomic and epigenomic determinants of heat stress-induced ...

To address this issue and understand the genome and epigenome architecture of transcriptional memory after heat stress, we identify the global ...

Gene bookmarking by the heat shock transcription factor programs ...

Depending on the duration of maternal heat stress exposure, this epigenetic memory is inherited by the next generation. Thus, paradoxically, HSF ...

Transcriptional response to stress is pre-wired by promoter ... - Nature

Activated Heat Shock Factor 1 (HSF1) binds to transcription-primed promoters and enhancers, and CTCF-occupied, non-transcribed chromatin. These ...

Diversification of heat shock transcription factors expanded thermal ...

Transcriptome and metabolome analyses of M. polymorpha HSF-null mutants revealed that MpHSFA1 controls canonical heat responses such as thermotolerance and ...

Highly dynamic transcriptional reprogramming and shorter isoform ...

Here, we used an invasive model species, Ciona savignyi, to investigate the temporary plastic changes under temperature stresses on gene expression and ...

The Interplay between Two Transcriptional Repressors and ... - MDPI

Moreover, an additional level of control of heat-shock genes' expression is exerted by a posttranscriptional feedback regulatory circuit in which chaperones ...

HSFA1a modulates plant heat stress responses and alters the 3D ...

Our data show that heat stress induces rapid changes in chromatin architecture, leading to the transient formation of promoter-enhancer contacts.

Characterisation of the global transcriptional response to heat shock ...

The heat shock transcriptional response is essential to effective cellular function under stress. This is a highly heritable trait but the ...

Yeast DJ-1 superfamily members are required for diauxic-shift ...

... shock, indicating that TORC1 inhibition restored normal heat-shock response (Fig. ... transcriptional reprogramming (11, 14, 25). We found that nutrient ...