Translating B cell immunology to the treatment of antibody|mediated ...

Translating B cell immunology to the treatment of antibody-mediated ...

Antibody-mediated rejection (AMR), including chronic AMR (cAMR), causes ~50% of kidney allograft losses each year.

Translating B cell immunology to the treatment of antibody-mediated ...

Request PDF | Translating B cell immunology to the treatment of antibody-mediated allograft rejection | Antibody-mediated rejection (AMR), including chronic ...

Translating B cell immunology to the treatment of antibody-mediated ...

The complexity of the pathogenesis of AMR and cAMR suggest that multiple approaches will probably be required to treat these disease processes effectively, ...

[Article] Translating B cell immunology to the treatment of antibody ...

https://www.nature.com/articles/s41581-023-00791-0 Peter S. Heeger, Maria Carrera Haro & Stanley Jordan Nature Reviews Nephrology (2024) ...

[Article] Translating B cell immunology to the treatment of antibody ...

[Article] Translating B cell immunology to the treatment of antibody-mediated allograft rejection by Peter S. Heeger, Maria Carrera Haro & ...

Translating B cell immunology to the treatment of antibody-mediated ...

Publications that cite this publication · Reduction of HLA antibodies by bi-specific antibody blinatumomab · Sequential administration of anti-complement ...

American Society of Pediatric Nephrology on X: "Translating B cell ...

Translating B cell immunology to the treatment of antibody-mediated allograft rejection https://t.co/11M5jZJgID @naTREVNEPH #Transplant.

Transplant immunology articles within Nature Reviews Nephrology

Antibody-mediated rejection is a key mechanism in allograft loss. Here, the authors examine advances in B cell biology and how they can inform the development ...

Approaches for Controlling Antibody-Mediated Allograft Rejection ...

Although T cells mediate the activation of the humoral immune response to transplanted grafts through activating B cells, efforts to control antibody-mediated ...

Overview of human B-cell development and antibody deficiencies

B cells are a key component of the humoral (antibody-mediated) immune response which is responsible for defense against a variety of pathogens.

Disrupting B and T-cell collaboration in autoimmune disease

B- and T-cell (B–T-cell) collaboration perpetuates chronic inflammation in a range of autoimmune diseases (AID) including rheumatoid arthritis (RA), systemic ...

Using Antigen-Specific B Cells to Combine Antibody and T Cell ...

B-cell effector functions could be exploited for cancer immunotherapy. A two-pronged approach in mice, combining antigen-specific CD40-activated B cells.

B cell depletion therapies in autoimmune diseases - Frontiers

Accumulating data indicates that treatments aiming to eliminate antibody-secreting cells (B cells or plasma cells) are effective in a wide spectrum of ...

Antibody-Mediated Coengagement of FcγRIIb and B Cell Receptor ...

Thus, amplification of the FcγRIIb inhibitory pathway in activated B cells may represent a novel B cell-targeted immunosuppressive therapeutic approach for SLE ...

Genome edited B cells: a new frontier in immune cell therapies

Recent advances in genome editing are now allowing reprogramming of B cells by site-specific engineering of the Ig locus with preformed antibodies.

Single-cell analysis of human B cell maturation predicts ... - Science

Our analyses reveal the dynamic cellular states that shape human B cell–mediated immunity and highlight how antibody isotype may play a role during their ...

B Cell Immunology - German Cancer Research Center

The Division of B Cell Immunology studies antibody responses in health and disease. Direct measurements of the composition of the antigen receptor repertoire ...

B cells reappear less mature and more activated after their anti ...

B cell depletion via anti-CD20 antibodies is a highly effective treatment for multiple sclerosis (MS). However, little is known about the ...

Unraveling B cell trajectories at single cell resolution - ScienceDirect

During adaptive immunity, B cells differentiate either into memory B cells or plasma cells and produce antibodies against foreign antigens to fight ...

SARS-CoV-2 Monoclonal Antibody Treatment Followed by ...

It has been observed that circulating antibodies can affect B-cell responses in multiple mouse models [8–12], in a process known as antibody ...