Translating DPYD genotype into DPD phenotype

Translating DPYD genotype into DPD phenotype - PubMed

The dihydropyrimidine dehydrogenase enzyme (DPD, encoded by the gene DPYD) plays a key role in the metabolism of fluoropyrimidines. DPD deficiency occurs in ...

Translating DPYD genotype into DPD phenotype - Future Medicine

The gene activity score is a new method for translating DPYD genotype into DPD phenotype. It can be used to standardize the process of ...

Translating DPYD genotype into DPD phenotype - PharmGKB

We propose the gene activity score for translating DPYD genotype into phenotype, accounting for differences in functionality of SNPs. This method can be used to ...

Translating DPYD genotype into DPD phenotype - Semantic Scholar

The gene activity score for translating DPYD genotype into phenotype is proposed, accounting for differences in functionality of SNPs, which can be used to ...

DPYD genotyping and dihydropyrimidine dehydrogenase (DPD ...

DPYD genotyping and measurements of plasma uracil concentration (DPD phenotyping) can be applied as tests for DPD deficiency. In April 2020, the European ...

CPIC® Guideline for Fluoropyrimidines and DPYD

Assignment of likely DPD phenotype based on DPYD genotype. Table 2 ... translations of diplotype to phenotype, and gene resource mappings. bThese ...

Dutch Pharmacogenetics Working Group (DPWG) guideline for the ...

In contrast to the DPYD genotyping test, which aims to predict DPD enzyme activity, a DPD phenotyping test can be performed to measure the ...

Translating DPYD genotype into DPD phenotype - ResearchGate

Abstract and Figures. The dihydropyrimidine dehydrogenase enzyme (DPD, encoded by the gene DPYD) plays a key role in the metabolism of ...

DPYD genotype-guided dose individualization to improve patient ...

Currently, most evidence on clinical validity and utility is available for individualized dosing based on DPYD genotype. However, several DPD phenotyping tests ...

Current diagnostic and clinical issues of screening for ...

In this review, we survey the evidence-based pharmacogenetics and therapeutic recommendations regarding DPYD (the gene encoding DPD) genotyping and DPD ...

Translating DPYD genotype into DPD phenotype

Translating DPYD genotype into DPD phenotype: using the DPYD gene activity score ; All authors: Henricks, L.M.; Lunenburg, C.A.T.C.; Meulendijks, D.; Gelderblom, ...

DPYD genotype-guided dose individualization to improve patient ...

Currently, most evidence on clinical validity and utility is available for individualized dosing based on DPYD genotype. However, several DPD phenotyping tests ...

DPD genotyping and phenotyping to prevent severe toxicity in ...

22 The gene activity score (GAS) is often used to translate the. DPYD genotype into a DPD phenotype to describe DPD activity and for dose recommendations.23 ...

Dihydropyrimidine dehydrogenase (DPD) enzyme deficiency - eviQ

DPD deficiency occurs in patients who carry genetic variations in the dihydropyrimidine dehydrogenase (DPYD) gene. Fluoropyrimidine toxicity. About 10-40% of ...

Pharmacogenomics - ResearchGate

In this paper, we describe a method for translation of DPYD genotype into DPD phenotype making use of the gene activity score. This method accounts for the ...

Translating DPYD genotype into DPD phenotype - Utrecht University

We propose the gene activity score for translating DPYD genotype into phenotype, accounting for differences in functionality of SNPs. This ...

DPYD preprint - CPIC

ASSIGNMENT OF LIKELY DPD PHENOTYPES BASED ON DPYD GENOTYPES ... Translating DPYD genotype into DPD phenotype: using the DPYD gene activity score.

Translating DPYD Genotype into DPD Phenotype - OUCI

Translating DPYD Genotype into DPD Phenotype: Using the DPYD Gene Activity Score · List of references · Publications that cite this publication.

Discrepancies between dihydropyrimidine dehydrogenase ...

This study, conducted on a large cohort, showed phenotyping and genotyping approaches for the screening of DPD deficiency to be discordant in ...

DPYD genotype-guided dose individualization to improve patient ...

Translating DPYD genotype into DPD phenotype: using the DPYD gene activity score. Pharmacogenomics 2015; 16(11): 1277–1286. 30. Van Staveren ...