Translocation of Proteins into the Mitochondria

The Transport of Proteins into Mitochondria and Chloroplasts - NCBI

Proteins are translocated into the mitochondrial matrix space by passing through the TOM and TIM complexes at sites of adhesion between the outer and inner ...

Translocation of proteins into mitochondria - PubMed

About 10% to 15% of the nuclear genes of eukaryotic organisms encode mitochondrial proteins. These proteins are synthesized in the cytosol and recognized by ...

Protein Translocation into the Intermembrane Space and Matrix of ...

All other proteins are synthesized in the cytosol from where they are imported into mitochondria by a translocase in the outer membrane of mitochondria (TOM ...

Mitochondrial protein translocation-associated degradation - Nature

Mitochondrial biogenesis and functions depend on the import of precursor proteins via the 'translocase of the outer membrane' (TOM complex).

Mitochondrial protein transport: Versatility of translocases and ...

The β-barrel protein Tom40 forms the channel for translocation of precursor proteins across the outer membrane. Six proteins with α-helical ...

Translocation of Proteins into Mitochondria

The translocase of the outer mitochondrial membrane (TOM) is composed of receptors, a channel protein, and its modulators that function together to import ...

The Protein Import System of Mitochondria

A protein destined to be imported into mitochondria is normally synthesized with a transient N-terminal extension that functions as a targeting signal. For ...

Common ground for protein translocation: access control for ... - Nature

For most precursor proteins, translocation into mitochondria (a) and chloroplasts (b) is mediated by the translocase of the outer membrane ...

Mechanisms of Protein Import into Mitochondria Review

The Importance of Surface Receptors for Outer. Membrane Translocation. Three proteins of the mitochondrial outer membrane. TOM machinery act as receptors for ...

Mitochondrial protein translocation machinery: From TOM structural ...

JBC Reviews. Mitochondrial protein translocation machinery: From TOM structural biogenesis to functional regulation.

Translocation of Proteins into the Mitochondria - JoVE

Chapter 16: Intracellular Compartments and Protein Sorting 16.10: Translocation of Proteins into the Mitochondria

Retro-translocation of mitochondrial intermembrane space proteins

Whether the reverse movement of unfolded proteins to the cytosol occurs across the intact outer membrane is unknown. We found that reduced, ...

Mechanisms of Protein Import into Mitochondria: Current Biology

Nuclear-encoded proteins, which are synthesised in the cytosol, are transported for example to organelles such as mitochondria, the endoplasmic reticulum (ER), ...

Translocation of precursor proteins into the mitochondrial matrix ...

All three are strongly associated with mitochondrial membranes, but can be extracted by protein denaturants such as urea. These translocational intermediates ...

Molecular Insights into Mitochondrial Protein Translocation ... - MDPI

Here, we will review the latest molecular details about mitochondrial protein import pathways. In addition, we will discuss new possible candidate genes.

Coordinated Translocation of Presequence-Containing Precursor ...

Though this basic concept also applies to protein translocation into mitochondria, the complex structure of this organelle brings many additional challenges.

Protein insertion into the inner membrane of mitochondria: routes ...

Most inner membrane proteins are encoded by nuclear genes and synthesized in the cytosol from where they are imported into mitochondria by ...

Protein translocation channel of mitochondrial inner membrane and ...

The majority of mitochondrial proteins are targeted to mitochondria by N-terminal presequences and use the TIM23 complex for their translocation ...

Translocation of Proteins into Mitochondria - Annual Reviews

Translocases in the outer and inner membrane of mitochondria me- diate the import and intramitochondrial sorting of these proteins;. ATP and the ...

From cytosol to mitochondria: the beginning of a protein journey

Mitochondrial protein import is one of the key processes during mitochondrial biogenesis that involves a series of events necessary for recognition and ...