Treatment response and recurrence of conjunctival melanoma with ...

CM with orbital invasion responds well to ICIs, with manageable toxic effects. Despite the complete resolution, close observation is needed as the recurrence ...

Advances in the Management of Conjunctival Melanoma - PMC

[107] Given the ocular surface toxicity, a drug holiday is often given, a few days to a week off treatment to allow for the ocular surface to heal. Mild topical ...

Of the 29 cases identified, complete resolution of ocular melanoma was achieved in 15 patients, representing 52% of the cases collectively, and none of them ...

Conjunctival Melanoma, Part 1: Can Systemic Therapies Save Eyes?

These cases were all locally advanced, recurrent, and some also had metastatic disease. So, I think we can expect a good response rate in ...

Periocular granulomatous inflammatory lesions mimicking ...

Treatment of conjunctival melanoma includes wide surgical excision accompanied by cryotherapy. The recurrence rate ranges from 36 to 62%, while metastasis ...

Conjunctival melanoma treatment outcomes in 288 patients

Despite close surveillance and intensive therapy at subspeciality centres, the 10-year tumour recurrence rates are reported to be as high as 69%. Reported risk ...

Conjunctival Melanoma: Risk Factors for Recurrence, Exenteration ...

Melanoma recurrence was defined as the development of a new histopathologically confirmed malignant melanoma at any site on the conjunctiva or ocular adnexa ...

Treatment of Conjunctival Melanoma Cell Lines With a Light ... - IOVS

Purpose: Conjunctival melanoma (CJM) is a rare malignant ocular surface tumor, which often leads to local recurrences and metastases.

Checkpoint inhibition immunotherapy for advanced local and ...

Herein, we describe the use of systemic immunotherapy for both locally advanced and metastatic conjunctival melanoma. Current treatments for ...

Conjunctival melanoma with pronounced central corneal invasion

Surgical excision followed by intraoperative and postoperative mitomycin c exposure was a successful primary treatment. Currently there are no signs of tumor ...

Small but Challenging Conjunctival Melanoma: New Insights ... - MDPI

Despite wide surgical excision followed by adjuvant therapy, about one third and one quarter of patients will experience local recurrence and ...

Systemic Treatment of Metastatic Conjunctival Melanoma - 2017

Conjunctival melanoma (CM) is an exceptionally rare tumor, with a propensity for local and distant recurrence, with the lungs, skin, liver, ...

Current Management of Conjunctival Melanoma Part 2: Treatment ...

The mainstays of treatment can be classified as surgery, topical chemotherapy, radiotherapy, cryotherapy, and other emerging treatment modalities.

Treatment of conjunctival melanoma cell lines with belzupacap ...

Purpose : Conjunctival melanoma (CoM) is a rare and malignant ocular tumor. After treatment of the primary tumor, 50% of patients may develop a local ...

Conjunctival melanoma with orbital invasion and liver metastasis ...

[1] In a study of 382 cases by Shields et al., an estimated 59% of treated cases showed recurrence or new growth after 10 years and 19% demonstrated metastases.

Clinical Management of Uveal and Conjunctival Melanoma

To date, adjuvant therapy after the initial management of a primary uveal melanoma has not been shown to affect the risk of relapse or death.

Conjunctival Melanoma: A Clinical Review and Update - MDPI

and risk of tumour recurrence are very high (33–61%), warranting close life-long follow-up [4,28,29,30,31,72]. Lymph node metastases are common (~25–52%; ...

Conjunctival Melanoma: Rare but Deadly

If a patient with known conjunctival melanoma develops recurrent PAM, it is advisable to treat the melanosis promptly before melanoma develops ...

Current Treatment of Conjunctival Malignancies - SpringerLink

Melanocytic and nonmelanocytic tumors were primarily managed with surgical excision, with relatively high recurrence rates and frequent ...

NF1 mutations in conjunctival melanoma | British Journal of Cancer

Conjunctival melanoma accounts for 5–10% of all ocular melanomas with a 10-year local recurrence rate of 38–69% and disease-related mortality of ...