Tumor Spheroid Uptake of Fluorescent Nanodiamonds is Limited by ...

Tumor Spheroid Uptake of Fluorescent Nanodiamonds is Limited by Mass Density: a 4D Light-Sheet Assay · Find this author on Google Scholar · Find ...

Tumor selective uptake of drug-nanodiamond complexes improves ...

Here we show that poly(ethylene glycol)-functionalized nanodiamonds loaded with doxorubicin (ND-PEG-DOX) afforded a considerable improvement over free drug in ...

Penetration and Uptake of Nanoparticles in 3D Tumor Spheroids

(8,16) However, their penetration through the spheroid was slow and limited to the outer cell layers of the spheroid, ∼30–50 μm depth from the ...

Spatio-temporal analysis of nanoparticles in live tumor spheroids ...

Nanoparticle uptake was shown to inversely relate to particle size and varied depending on the cell type, cell stiffness and density of the spheroid model. The ...

Size‐Dependent Penetration of Nanoparticles in Tumor Spheroids ...

The results reveal that 15 nm nanoparticles penetrate spheroids mainly through an energy-independent transcellular pathway, while 60 nm ...

Three-Dimensional Tumor Spheroids as a Tool for Reliable ...

The uptake of the GNPs on a single cell level depends on many different factors, including size, shape, and surface functionalization [29,30].

Nanodiamond in cancer theranostics - ScienceDirect.com

In one study, NDs were hybrid with gold/silver nanoparticles and used for effective photothermal therapy for cancer [120]. Choi et al. fabricated FA-ND ...

Heterotypic tumor spheroids: a platform for nanomedicine evaluation

Therefore, producing in vitro models to investigate the penetration of NPs into tumor tissue is of great interest and importance. Co-culture ...

Cellular uptake and tumor spheroid penetration of AsNPs. Notes

Cellular uptake and tumor spheroid penetration of AsNPs. Notes: (A) Cellular uptake of AgNPs, PNPs and AsNPs as assessed by dark-field imaging.

Multicellular tumor spheroids: a relevant 3D model for the in vitro ...

Large spheroids (∼400–500 μm diameter) display an internal layered cell distribution analogous to that observed in solid tumors. This is the ...

Lipid Membrane Alterations in Tumor Spheroids Revealed by ...

The average fluorescence lifetime value of the 3D tumor spheroids was approximately 3800 ps. Figure 2b shows that the 2D tumor cells were grown ...

A fluorescent nanodiamond foundation for quantum sensing in cells

Chapter 3 focuses on the forced uptake mechanism of chemical transformation in yeast cells. The influence of the transformation procedure and diamond uptake is ...

Surface Modification of Fluorescent Nanodiamonds for Biological ...

... absorption of the NV fluorescence. The PL intensity of PDA coated FND ... Preferential Tumor Accumulation of Polyglycerol Functionalized Nanodiamond ...

Enhanced penetrative siRNA delivery by a nanodiamond drug ...

Niora et al. compared the penetration efficiency of lipid-based nanoparticles into tumor spheroids and found that LPX showed relatively low ...

Targeting of 4T1 spheroids by functionalized nanodiamonds within a ...

... tumor microenvironment: (a) Uptake of targeted nanodiamond complex NDA135b by particular cells within a spheroid MF co-culture. The average percentage of ...

university of copenhagen - CORE

NP Tumor Spheroid Penetration. The imaging of a dense spheroid is in brief limited by two conditions: (i) the attenuation of the fluorescence ...

Biophysics - bioRxiv

https://doi.org/10.1101/2024.11.13.623460 New Results. Add to Selected Citations · Tumor Spheroid Uptake of Fluorescent Nanodiamonds is Limited by Mass Density: ...

3D spheroid cultures for evaluation of nanophotosensitizers ...

Consequently, these properties of ICG NPs makes it is the most promising PS for fluorescent diagnosis of deep-seated tumors. Figure 2. The absorption spectrum ...

Fluorescent nanodiamond for nanotheranostic applications - OUCI

... fluorescent nanodiamonds for optimal delivery of active siRNA to a xenografted tumor in mice. ... fluorescent nanodiamond uptake. Sensors 18. https://doi ...

Surface engineering and applications of nanodiamonds in cancer ...

The cellular uptake study revealed that the coated non-toxic FNDs could be internalised into HEK 293 cells via the endocytic pathway. Fluorescent glyco single- ...