Tumor methionine metabolism drives T|cell exhaustion in ...

Tumor methionine metabolism drives T-cell exhaustion in ... - Nature

Our results reveal the central role of tumor methionine recycling pathway as a driver of T-cell dysfunction in HCC, leading tumor immune evasion.

Tumor methionine metabolism drives T-cell exhaustion in ... - PubMed

Here, we find T-cell exhaustion linked to overall survival in 675 hepatocellular carcinoma (HCC) patients with diverse ethnicities and etiologies.

Abstract 1687: Tumor methionine metabolism drives T-cell ...

Abstract. IntroductionExhausted T cells (ETC) denotes a hypofunctional state of T lymphocyte that is commonly seen in cancer. Chronic T-cell ...

Tumor methionine metabolism drives T-cell exhaustion in ...

T-cell exhaustion denotes a hypofunctional state of T lymphocytes commonly found in cancer, but how tumor cells drive T-cell exhaustion remains elusive.

Methionine consumption by cancer cells drives a progressive ...

In addition, targeting T cell metabolism can improve anti-cancer immunotherapy. The roles of several amino acids on CD8 T cell regulation and ...

Tumor methionine metabolism drives T-cell exhaustion ... - Metabolon

Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma. Author: Year Published: 2021. Media Outlet: Open Access? No. Matrix:.

(PDF) Tumor methionine metabolism drives T-cell exhaustion in ...

Integrative omics analyses uncover oncogenic reprograming of HCC methionine recycling with elevated 5-methylthioadenosine (MTA) and S-adenosylmethionine (SAM) ...

Methionine consumption by cancer cells drives a progressive ...

... methionine-dependent regulator of the epigenetic control of PD-1 expression in CD4 T cells, a metabolic checkpoint for CD4 T cell exhaustion.

Tumor methionine metabolism drives T-cell exhaustion in ... - Ex Libris

T-cell exhaustion denotes a hypofunctional state of T lymphocytes commonly found in cancer, but how tumor cells drive T-cell exhaustion remains elusive.

Tumor methionine metabolism drives T-cell exhaustion in HCC

Xin Wei Wang, PhD, National Institute of Health, Bethesda, MD, outlines the results of an integrative omics analysis, identifying tumor ...

Methionine cycle-dependent regulation of T cells in cancer immunity

... T cells (37). Tumor methionine metabolism drives T cell exhaustion. T cell exhaustion is a common state induced by chronic antigen exposure ...

Molecular insight into T cell exhaustion in hepatocellular carcinoma

Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma. Nat. Commun., 12 (1) (2021), p. 1455. View in Scopus Google Scholar. [70]. W ...

Tumor methionine metabolism drives T-cell exhaustion in ...

Integrative omics analyses uncover oncogenic reprograming of HCC methionine recycling with elevated 5-methylthioadenosine (MTA) and S-adenosylmethionine (SAM) ...

Methionine cycle-dependent regulation of T cells in cancer immunity

... T cells (37). Tumor methionine metabolism drives T cell exhaustion. T cell exhaustion is a common state induced by chronic antigen exposure ...

Tumor drives T cell exhaustion by manipulating the methionine cycle ...

On the other hand, hepatocellular carcinoma (HCC) tumors may produce immune-suppressive metabolites through methionine metabolism that help to induce T cell ...

Tumor methionine metabolism drives T-cell exhaustion in ... - OUCI

AbstractT-cell exhaustion denotes a hypofunctional state of T lymphocytes commonly found in cancer, but how tumor cells drive T-cell exhaustion remains ...

Targeting methionine metabolism in cancer - ScienceDirect.com

Methionine metabolism: an attractive target for cancer therapy · Tumor cell dependence on methionine · Tumorigenesis drives methionine metabolism in cancers.

The role of tumor metabolism in modulating T-Cell activity and in ...

... drives T-cell exhaustion (74–76). As is true for glucose metabolism, T cells ... Cancer Slc43a2 alters T cell methionine metabolism and histone methylation.

Fueling T-cell Antitumor Immunity: Amino Acid Metabolism Revisited

... drive intratumoral T-cell metabolic insufficiency and ... Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma.

Microenvironmental ammonia enhances T cell exhaustion in ...

Moreover, Kras mutations are known to drive glutamine metabolism, which is in line with TripleMut ... Cancer. SLC43A2 alters T cell methionine metabolism and ...