Two|Phase Lineage Specification of Telencephalon Progenitors ...

Two-Phase Lineage Specification of Telencephalon Progenitors ...

This study reveals a novel developmental mechanism for telencephalon patterning that relies on the interplay of dose- and time-dependent signaling.

Two-Phase Lineage Specification of Telencephalon Progenitors ...

Proper brain development requires precisely controlled phases of stem cell proliferation, lineage specification, differentiation, ...

Two-Phase Lineage Specification of Telencephalon Progenitors ...

Cortical fate (Pax6+/Foxg1+) was a default (signal-independent) state in the early stage. These suggest that the fate of most telencephalic ...

Two-Phase Lineage Specification of Telencephalon Progenitors ...

Lineage specification depends partly on concentration gradients of chemical cues called morphogens. However, the rostral brain (telencephalon) expands ...

Two-Phase Lineage Specification of Telencephalon Progenitors ...

Two-Phase Lineage Specification of Telencephalon Progenitors Generated From Mouse Embryonic Stem Cells. Makoto Nasu. ,. Shigeyuki Esumi. ,. Jun Hatakeyama.

Two-Phase Lineage Specification of Telencephalon Progenitors ...

Proper brain development requires precisely controlled phases of stem cell proliferation, lineage specification, differentiation, and migration.

Two-Phase Lineage Specification of Telencephalon Progenitors ...

Two-Phase Lineage Specification of Telencephalon Progenitors Generated From Mouse Embryonic Stem Cells. Makoto Nasu 1. ,. Shigeyuki Esumi 2. ,. Jun Hatakeyama 3.

Two-phase specification model for telencephalon patterning. Fate of...

... the late phase through a temporal shift in progenitor states for the Shh response. from publication: Two-Phase Lineage Specification of Telencephalon ...

Molecular mechanisms underlying cell fate specification in the ...

Similarly, the ventral telencephalon consists of two distinct progenitor domains, the lateral (LGE) and medial (MGE) ganglionic eminences, generating the ...

Developmental programming and lineage branching of early human ...

Generating variable human telencephalic neurons from corresponding regional progenitors follows temporal cell fate transition from NE to RGs to IPCs_div, and ...

Formation of dorsal–ventral axis of the pallium derived from mouse ...

Two-Phase Lineage Specification of Telencephalon Progenitors Generated From Mouse Embryonic Stem Cells. 2021, Frontiers in Cell and Developmental Biology.

Hedgehog-dependent oligodendrocyte lineage specification in the ...

In the caudal neural tube, oligodendrocyte progenitors (OLPs) originate in the ventral neuroepithelium under the influence of Sonic hedgehog ...

Telencephalic Neural Progenitors Appear To Be Restricted to ...

The contribution of cell lineage to the complex anatomical organization of the telencephalon is unclear. It has been postulated that a lineally ...

Amplification of progenitors in the mammalian telencephalon ...

We observe lineage amplification by a new type of progenitor, including bipolar radial glial cells dividing at subapical positions and generating further ...

Neuronal lineage tracing from progenitors in human cortical ...

Surprisingly, nearly all excitatory neurons produced in cortical organoids were generated indirectly from intermediate progenitor cells. Additionally, neurons ...

Radial glia in the ventral telencephalon - Turrero García - FEBS Press

... specification of progenitors in the ventral telencephalon. ... progenitors through the production of these two lineages [39]. The ...

Identification of two novel glial-restricted cell populations in the ...

We have identified progenitor populations in the ventral and dorsal telencephalon restricted to the generation of astrocytes and oligodendrocytes.

Telencephalic Neural Progenitors Appear To Be Restricted to ...

We have been able to study cell lineage in the telencephalon from the onset of neurogenesis by using ultrasound backscatter microscopy to label the forebrain.

Molecular programs of regional specification and neural stem cell ...

Regionalization of macaque telencephalon. Single-cell transcriptomics of prenatal macaque telencephalic regions distinguished subtypes spanning ...

https://www.frontiersin.org/journals/cell-and-developmental-biology ...

... specification and a temporal shift in cellular Shh sensitivity. This delayed fate choice through two-phase specification allows tissues with marked size ...