Two modes of cis|activation of switch transcription by the IgH ...

Two modes of cis-activation of switch transcription by the IgH ... - PNAS

We show that there are two modes of 3′RR-mediated activation of I promoters: coactivation and competition.

Two modes of cis-activation of switch transcription by the IgH ...

We show that there are two modes of 3'RR-mediated activation of I promoters: coactivation and competition.

Two modes of cis-activation of switch transcription by the IgH ... - PNAS

The transcribed switch regions can recombine, leading to a change of the constant gene and, consequently, of antibody isotype. Switch ...

[PDF] Two modes of cis-activation of switch transcription by the IgH ...

Two modes of cis-activation of switch transcription by the IgH superenhancer · Joana M. Santos, Fatima-Zohra Braikia, +2 authors. A. Khamlichi · Published in ...

Two modes of cis-activation of switch transcription by the IgH ...

B cell isotype switching plays an important role in modulating adaptive immune responses. It occurs in response to specific signals that often induce ...

Two modes of cis-activation of switch transcription by the IgH ... - HAL

Two modes of cis-activation of switch transcription by the IgH superenhancer. Joana M Santos , Fatima-Zohra Braikia (1) , Chloé Oudinet (2) , Audrey Dauba (3) ...

A novel regulatory region controls IgH locus transcription and switch ...

Class switch recombination (CSR) occurs at the IgH locus and replaces the immunoglobulin (Ig) isotype expressed from IgM to IgG, IgE or IgA, ...

Genetic Instability and Transcriptional Regulation - IPBS-Toulouse

(2019) Two modes of cis-activation of switch transcription by the IgH superenhancer. Proc Natl Acad Sci USA Jamrog*, Chemin* et al. (2018) PAX5-ELN ...

Essential role of the initial activation signal in isotype selection upon ...

... switch transcription and CSR ... & Khamlichi, A. A. Two modes of cis-activation of switch transcription by the IgH superenhancer.

Mechanism and regulation of class switch recombination by IgH ...

AID initiates DNA double-strand breaks (DSBs) intermediates that are repaired by general DNA repair pathways. Switch transcription is controlled by various ...

Essential role of the initial activation signal in isotype selection upon ...

... Two modes of cis -activation of switch transcription by the IgH superenhancer. Santos J.M., Braikia F., Oudinet C., Dauba A., Khamlichi A.A.. Q1. Proceedings ...

Mechanism and regulation of class switch recombination by IgH ...

... IgH locus - Class switch recombination - Switch transcription ... Two modes of cis-activation of switch transcription by the IgH superenhancer.

Long-Range Control of Class Switch Recombination by ... - Frontiers

Two Modes of Cis-Activation of Switch Transcription by the IgH Superenhancer. Proc Natl Acad Sci USA (2019) 116:14708–13. doi: 10.1073/pnas ...

IgH Chain Class Switch Recombination: Mechanism and Regulation

Class switching occurs by a deletional recombination between two switch regions, each of which is associated with a H chain constant region gene ...

Aryl hydrocarbon receptor-induced activation of the human IGH hs1 ...

1) (Roy et al., 2011). In vivo mouse models have identified an essential role of the mouse 3′IghRR in modulating transcription of the Igh gene, class switch ...

Lineage tracing reveals B cell antibody class switching is stochastic ...

In turn, these CSR patterns resulted from independent all-or-none expression of both activation-induced cytidine deaminase (AID) and IgH germline transcription ...

Modulation of the IgH enhancer's cell type specificity through a ...

was manifested in two ways. First, with the exception of the VI promoter ... IgH enhancer to tissue specific transcriptional activation. Nucleic Acids ...

Interplay of cis and trans mechanisms driving transcription factor ...

Cis-acting variants lead to local coordination of transcription factor occupancies that decay with distance; distal coordination is also ...

Mediator facilitates transcriptional activation and dynamic long ...

Thomas-Claudepierre et al. report that mediator facilitates the long-range contacts between acceptor switch regions and the IgH locus ...

NF-κB and Oct-2 Synergize to Activate the Human 3 - AAI Journals

Independent modes of transcriptional activation by the p50 and p65 subunits of NF-κB. ... Transcriptional regulation of the murine 3′ IgH enhancer by OCT-2.