Type 1 diabetes genetic risk score is discriminative of ...

Type 1 diabetes genetic risk score is discriminative of ... - PubMed

The T1D GRS was discriminative of T1D from T2D in Indians but slightly less than in Europeans (ROC AUC 0.84 v 0.87, p < 0.0001). HLA SNPs ...

Type 1 diabetes genetic risk score is discriminative of ... - Nature

The T1D GRS was discriminative of T1D from T2D in Indians but slightly less than in Europeans (ROC AUC 0.84 v 0.87, p < 0.0001). HLA SNPs ...

A Type 1 Diabetes Genetic Risk Score Can Aid Discrimination ...

Most discriminative ability was obtained from just nine single nucleotide polymorphisms (AUC 0.87). In young adults with diabetes, T1D GRS alone ...

Impact of HLA diversity on the lower discriminative ability - medRxiv

Type 1 Diabetes Genetic Risk Score classifies diabetes subtypes in Indians: Impact of HLA diversity on the lower discriminative ability.

Utility of genetic risk scores in type 1 diabetes | Diabetologia

GRS1 was highly effective in discriminating type 1 from type 2 diabetes (AUC=0.87), with most discriminative power provided by the top nine SNPs ...

Type 1 diabetes genetic risk score is discriminative of diabetes in ...

The T1D GRS was discriminative of T1D from T2D in Indians but slightly less than in Europeans (ROC AUC 0.84 v 0.87, p < 0.0001). HLA SNPs ...

Type 1 diabetes genetic risk score discriminates between ...

discriminative ability of the Type 1 diabetes genetic risk score and antibodies in a larger cohort of people with diabetes diagnosed up to ...

Application of a Genetic Risk Score to Racially Diverse Type 1 ...

As expected, it was less effective at discriminating type 1 diabetes from first-degree relatives (65.0% specificity, 67.4% sensitivity, AUROC = ...

(PDF) Type 1 diabetes genetic risk score is discriminative of ...

The T1D GRS was discriminative of T1D from T2D in Indians but slightly less than in Europeans (ROC AUC 0.84 v 0.87, p < 0.0001). HLA SNPs contributed the ...

Impact of HLA diversity on the lower discriminative - medRxiv

Discrimination Between Type 1 and Type 2 Diabetes in Young Adults. ... Figure 1: Discriminative ability of T1D genetic risk score in Indians.

Clinical and research uses of genetic risk scores in type 1 diabetes

We first tested the discriminatory ability of a 30 SNP T1D GRS containing HLA and non-HLA loci in gold standard T1D and. T2D patients from the WTCCC [22, 46].

Type 1 diabetes genetic risk score discriminates between ...

To examine the extent to which discriminatory testing using antibodies and Type 1 diabetes genetic risk score, validated in European populations ...

A type 1 diabetes genetic risk score can discriminate monogenic ...

Age of diabetes diagnosis and type 1 diabetes GRS combined to be highly discriminatory of monogenic autoimmunity (receiver operating ...

Clinical and research uses of genetic risk scores in type 1 diabetes

This type of approach underrepresents the discriminative power of genetic information by not quantifying the risk associated with DR3 and. Genetic risk scores ...

Genetic Risk Scores for Diabetes Diagnosis and Precision Medicine

They found that the T1D rsPS was highly discriminative (AUROC of 0.88), whereas the T2D EPS was less so (AUROC of 0.64), and that combining the ...

Type 1 diabetes genetic risk score is discriminative of ... - OUCI

HLA SNPs contributed the majority of the discriminative power in Indians. A T1D GRS using SNPs defined in Europeans is discriminative of T1D from T2D and ...

Genetic risk score can differentiate type 1, 2 diabetes - Medical Xpress

A low T1D GRS (<0.234) had 53 percent sensitivity and 95 percent specificity for T2D. Most of the discriminative ability came from nine single ...

Type 1 Diabetes Genetic Risk Score

The type 1 diabetes genetic risk score is a new addition to our testing pathway to identify individuals in whom genetic testing for monogenic diabetes is ...

Type 1 diabetes in diverse ancestries and the use of genetic risk ...

Harrison, JW ∙ Tallapragada, DSP ∙ Baptist, A ∙ et al. Type 1 diabetes genetic risk score is discriminative of diabetes in non-Europeans: ...

(PDF) A Type 1 Diabetes Genetic Risk Score Can Aid Discrimination ...

Most discriminative ability was obtained from just nine single nucleotide polymorphisms (AUC 0.87). In young adults with diabetes, T1D GRS alone ...