Type 1 diabetes in diverse ancestries and the use of genetic risk ...

Over 75 genetic loci within and outside of the HLA region influence type 1 diabetes risk. Genetic risk scores (GRS), which facilitate the integration of ...

Unlike other non-Mendelian diseases, type 1 diabetes has a major genetic risk factor—the human MHC on chromosome 6p21.3, with the HLA class I ( ...

Type 1 diabetes in diverse ancestries and the use of genetic risk ...

Nearly one-half of the genetic risk of T1D is due to variation in the HLA class I (A, B, C) and class II (DR, DQ, DP) genes. HLA risk in non-European ...

11.10. Type 1 diabetes in diverse ancestries and the use of genetic ...

T1D has a major genetic risk factor, the human MHC on chromosome 6p21.3 with HLA class I and class II genes contributing 33–50% of genetic risk. As a result, ...

Genetics of Type 1 Diabetes - NCBI

The genetic risk ratio in siblings (lambda-s), which is defined as the ratio of the risk in siblings of individuals with the disease to the ...

Application of a Genetic Risk Score to Racially Diverse Type 1 ...

Prior studies identified HLA class-II and 57 additional loci as contributors to genetic susceptibility for type 1 diabetes (T1D).

Type 1 diabetes in diverse ancestries and the use of genetic risk ...

Type 1 diabetes in diverse ancestries and the use of genetic risk scores. ; Redondo, Maria J · None · The Lancet. Diabetes & Endocrinology · Aug ...

Type 1 Diabetes Genetic Research Could Prompt New Guidelines

An international team of scientists led by a UVA Health genomics researcher published the largest and most ancestry-diverse genetic study of ...

Type 1 Diabetes Risk in African-Ancestry Participants and Utility of ...

HLA class I and class II alleles were imputed using SNP2HLA. Logistic regression models were used to identify genome-wide significant (P < 5.0 × ...

Utility of genetic risk scores in type 1 diabetes | Diabetologia

Most early studies of type 1 diabetes genetics have been conducted in European ancestry populations, but, to develop accurate GRSs across ...

Type 1 diabetes in diverse ancestries and the use of genetic risk ...

Request PDF | On Sep 8, 2023, Redondo MJ and others published Type 1 diabetes in diverse ancestries and the use of genetic risk scores ...

Type 1 diabetes genetic risk score is discriminative of ... - Nature

In conclusion, we show that a 9 SNP T1D GRS can be used to help classify diabetes in Indians. This study suggests the T1D GRS could be an ...

A multi-ancestry genome-wide association study in type 1 diabetes

In GWAS meta-analysis, seven loci were associated with T1D risk at genome-wide significance: PTPN22, HLA-DQA1, IL2RA, RNLS, INS, IKZF4-RPS26- ...

Implementation of type 1 diabetes genetic risk screening in children ...

A custom genotyping panel was used to define T1D genetic risk based upon associated SNPs in European- and African-genetic ancestry. Subjects at ...

Type 1 Diabetes Genetic Risk Score Differentiates Subgroups of ...

All T1D GRS results and comparisons used the remaining 29 SNPs. Twenty-eight individuals were excluded based on missingness criteria. The range ...

Type 1 Diabetes in Diverse Ancestries and the Use of Genetic Risk ...

Over 75 genetic loci within and outside of the HLA region influence type 1 diabetes risk. Genetic risk scores (GRS), which facilitate the ...

Type 1 diabetes in diverse ancestries and the use of genetic risk ...

Type 1 diabetes in diverse ancestries and the use of genetic risk scores ... Authors: Maria J Redondo; Christopher R Gignoux; Dana Dabelea; William A Hagopian ...

Development and validation of a trans-ancestry polygenic risk score ...

Type 2 diabetes (T2D) is a common, chronic disease caused by both genetic and environmental risk factors and their interactions [1], which has ...

Genetic Risks in Type 1 Diabetes in Differing Ancestries

People with certain (HLA) human leukocyte antigen types like DR3 or DR4 have an increased genetic tendency of developing type 1 diabetes, and ...

Impact of HLA diversity on the lower discriminative ability - medRxiv

Objectives Genetic Risk scores (GRS) classify diabetes types, type 1 (T1D) and type 2 (T2D) in Europeans but the power is limited in other ...