Un|gating and allosteric modulation of a

Un-gating and allosteric modulation of a pentameric ligand ... - PLOS

Here, we provide the first atomistic description of the transition from open to closed (un-gating) in the glutamate-gated chloride channel (GluCl) from ...

Un-gating and allosteric modulation of a pentameric ligand-gated ...

Pentameric ligand-gated ion channels (pLGICs) mediate intercellular communication at synapses through the opening of an ion pore in response ...

(PDF) Un-gating and allosteric modulation of a pentameric ligand ...

Un-gating and allosteric modulation of a pentameric ligand-gated ion channel captured by molecular dynamics. PLOS Computational Biology. 13(10): ...

Un-gating and allosteric modulation of a pentameric ligand ... - OUCI

M Cecchini, The nicotinic acetylcholine receptor and its prokaryotic homologues: Structure, conformational transitions & allosteric modulation, ...

Allosteric Modulation as a Unifying Mechanism for Receptor ...

The ligand- and voltage-gated ion channels, G-protein-coupled receptors, nuclear hormone receptors, and receptor tyrosine kinases are all allosteric proteins ...

Allosteric Modulation as a Unifying Mechanism for Receptor ...

The ligand- and voltage-gated ion channels, G-protein-coupled receptors, nuclear hormone receptors, and receptor tyrosine kinases are all ...

Structure, function, and allosteric modulation of NMDA receptors

NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca 2+ -permeable component of excitatory neurotransmission in the central nervous ...

Allosteric modulation of ligand-gated ion channels - ScienceDirect

Here we review the allosteric modulation of LGICs in light of the latest findings and discuss the suitability of this approach to the design of new therapeutic ...

ATP-independent CFTR channel gating and allosteric modulation by ...

Unlike conventional ligand-gated channels, CFTR is an ATPase for which ligand (ATP) release typically involves nucleotide hydrolysis. The extent ...

Allosteric modulation of GABA A receptors by extracellular ATP

The γ-aminobutyric acid type A receptor (GABAAR) is a ligand-gated chloride ion channel, activation of which results in membrane ...

Zinc Inhibits Miniature GABAergic Currents by Allosteric Modulation ...

We provide evidence that inhibition of mIPSCs by Zn2+ is caused by allosteric modulation of GABAA receptor microscopic gating, including binding ...

Structural mechanisms of α7 nicotinic receptor allosteric modulation ...

The α7 nicotinic acetylcholine receptor is a pentameric ligand-gated ion channel that plays an important role in cholinergic signaling ...

Enhancement of muscimol binding and gating by allosteric ...

The binding of [3H]muscimol has been used to evaluate the distribution of GABAA receptors in the brain, and studies of modulation of [3H]muscimol binding by ...

Enhancement of Muscimol Binding and Gating by Allosteric ...

The model has been used extensively in analysis of electrophysiological data of activation and modulation of the GABAA receptor by orthosteric ...

Allosteric modulator - Wikipedia

In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimuli.

The binding and mechanism of a positive allosteric modulator of Kv3 ...

Small-molecule modulators of diverse voltage-gated K+ (Kv) channels may help treat a wide range of neurological disorders.

Drug Development in Channelopathies: Allosteric Modulation of ...

This thematic review highlights the discovery of representative allosteric modulators for ligand-gated and voltage-gated ion channels.

Un-gating and allosteric modulation of a pentameric ligand-gated ...

Un-gating and allosteric modulation of a pentameric ligand-gated ion channel captured by molecular dynamics. Nicolas E Martin1, Siddharth ...

Development of Allosteric Modulators of Voltage-Gated Na>+ ...

Development of Allosteric Modulators of Voltage-Gated Na+ Channels: A Novel Approach for an Old Target. / Dvorak, Nolan M.; Wadsworth, Paul A.; ...

TRPML1 gating modulation by allosteric mutations and lipids - eLife

This important report describes local and global structural changes driven by binding of regulatory phospholipids and by mutations that allosterically cause ...