Unbiased Proteomics of Early Lewy Body Formation Model ...

Parkinson's disease (PD) patients progressively accumulate intracytoplasmic inclusions formed by misfolded α-synuclein known as Lewy bodies ...

We identified proteins previously found in authentic LBs in PD as well as several novel proteins, including the microtubule affinity-regulating kinase 1 (MARK1 ...

Unbiased Proteomics of Early Lewy Body Formation Model ...

Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies.

Unbiased Proteomics of Early Lewy Body Formation Model ...

Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies. by Michael X ...

The process of Lewy body formation, rather than simply α-synuclein ...

Although converging evidence point to α-synuclein aggregation and Lewy body (LB) formation as central events in Parkinson's disease, ...

Network proteomics of the Lewy body dementia brain reveals ...

... unbiased network proteomic analysis revealed diverse pathophysiological changes in the LBD frontal cortex distinct from alterations in AD ...

Selectivity of Lewy body protein interactions along the aggregation ...

The aggregation of alpha-synuclein (α-SYN) follows a cascade of oligomeric, prefibrillar and fibrillar forms, culminating in the formation ...

The process of Lewy body formation, rather than simply alpha ...

Having a neuronal model that allows for unlinking of the key processes involved in LB formation is crucial for elucidating the molecular and ...

Quantitative proteomic analysis of mitochondrial proteins

The mechanisms underlying Parkinson's disease (PD) and Lewy body (LB) formation, a pathological hallmark of PD, are incompletely understood; however, ...

Plasma proteomics identify biomarkers predicting Parkinson's ...

Complement activation has been associated with the formation of α-synuclein and Lewy bodies in PD and deposits of the complement factors iC3b ...

The process of Lewy body formation, rather than simply α-synuclein ...

Although converging evidence point to α-synuclein aggregation and Lewy body (LB) formation as central events in Parkinson's disease, the molecular ...

From protein biomarkers to proteomics in dementia with Lewy Bodies

This review summarizes the widely used proteomic methods and presents evidence for protein dysregulation in the brain and peripheral tissues in DLB.

Proteomic identification of novel proteins associated with Lewy bodies.

Here, we present a comprehensive analysis of protein elements in Lewy bodies by comparative mass spectrometry. Cortical LB inclusions were enriched by sucrose ...

An iTRAQ-based proteomic analysis reveals dysregulation of ...

To understand the global proteomic changes that occurred in the BA9 area of the prefrontal cortex of Lewy body dementias, we pooled equal amount ...

The process of Lewy body formation, rather than simply alpha ...

Unbiased Proteomics of Early Lewy Body Formation Model Implicates. Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies.

Comprehensive proteomics of CSF, plasma, and urine identify DDC ...

We discovered that hundreds of proteins were upregulated in the CSF, blood, or urine of PD patients, prodromal PD patients with DAT deficit and ...

Defining a Lewy Body: Running Up the Hill of Shifting Definitions ...

Lewy bodies (LBs) are pathological hallmarks of Parkinson's disease and dementia with Lewy bodies, characterized by the accumulation of α-synuclein (αSyn) ...

[PDF] Broad proteomics analysis of seeding-induced aggregation of ...

4 Excerpts. Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies.

The process of Lewy body formation, rather than simply α-synuclein ...

M. X. Henderson ., Unbiased proteomics of early Lewy body formation model implicates active microtubule affinity-regulating kinases (MARKs) in synucleinopathies ...

Systems-based proteomics to resolve the biology of Alzheimer's ...

A growing body of evidence in mouse models indicates alterations in synaptic networks, prior to the onset of gross neuronal loss in the cerebral ...