Uncontrolled severe T2 asthma

Uncontrolled severe T2 asthma: Which biological to choose? A ...

In this article, an algorithm to choose the first biological drug in a specific patient is proposed based on different study results and patient' ...

Uncontrolled severe T2 asthma: Which biological to choose? A ...

In this article, an algorithm to choose the first biological drug in a specific patient is proposed based on different study results and patient' ...

When Asthma Is More Than Just Asthma: Type 2 Inflammation

When there are too many eosinophils in the blood, it can cause eosinophilic inflammation and an increased risk of severe asthma flares. This is known as ...

Severe Asthma | American Lung Association

Uncontrolled asthma is often defined by the frequency of symptoms. For example: Daytime asthma symptoms (e.g., shortness of breath, chest tightness, cough) more ...

Burden of Uncontrolled Severe Asthma With and Without Elevated ...

Many patients with asthma have type-2 airway inflammation, identified by the presence of biomarkers, including history of allergy, high blood eosinophil (EOS) ...

Eosinophils and T2 inflammation in severe asthma

T2 high asthma is defined as asthma where type 2 inflammation predominates with eosinophilic infiltration of the airways [11]. It is accompanied by elevated ...

Immunologic Basis of Type 2 Biologics for Severe Asthma

Even more, some asthmatic patients (called those with severe asthma, SA) remain uncontrolled despite regular treatment including medium-to-high- ...

Insights Into the Heterogeneity of Non-Type 2 Inflammation

Asthma is a chronic airway inflammatory disorder with heterogeneous pathogenic causes and various phenotypes. The phenotype of uncontrolled ...

P154 Characterization of uncontrolled severe asthma patients with ...

This study estimated the proportion of uncontrolled, high-dose ICS asthma patients in the Eurasian Middle East (EME) region based on T2 comorbidities and ...

Type 2 Low Biomarker Stability and Exacerbations in Severe ... - MDPI

exacerbation rates in T2 low and non-T2 low asthma from clinical retrospective data of severe uncontrolled asthma patients. Knowledge of the T2 ...

T2 low have limited effective treatment options - Dove Medical Press

Conclusion: Patients with uncontrolled severe T2 low asthma use equal healthcare resources as corresponding non-T2 low patients. This study ...

Advances in non-type 2 severe asthma: from molecular insights to ...

Among those individuals with T2 asthma, 81.1% had allergic asthma and 59.2% had eosinophilic asthma [10]. In addition, a distinct subtype of asthma, referred to ...

An algorithmic approach for the treatment of severe uncontrolled ...

After allocating a severe asthma patient to the T2-high endotype, it is also necessary to assess which endotype, i.e. allergic or eosinophilic, is predominant.

Biomarkers for predicting type 2-high and uncontrolled asthma in ...

Blood eosinophil count (BEC), immunoglobulin (Ig) E, and fractional exhaled nitric oxide (FeNO) are key clinical indicators for identifying type 2 (T2) asthma.

Defining type 2 asthma and patients eligible for dupilumab in Italy

... 2 inflammation. Dupilumab has been recently approved for the treatment of uncontrolled severe Type 2 asthma. Type 2 asthma includes allergic ...

Corrigendum: Uncontrolled severe T2 asthma: Which biological to ...

Severe asthma (SA) requires high doses of inhaled corticosteroids (ICS) associated to another controller medication (long-acting beta 2 ...

Prevalence, T2 Biomarkers, and Cost of Severe Asthma in the Era of ...

Asthma was severe in 3031 of these patients (7.7%), 81.2% of whom presented T2 asthma. Among patients with severe asthma, 64.1% had uncontrolled disease, 31.2% ...

Characterization of uncontrolled, severe asthma patients with type 2 ...

Conclusion: This research revealed that 65% of patients had at least one of three T2 inflammation comorbidities assessed: allergic rhinitis, chronic ...

Specific Therapy for T2 Asthma - MDPI

Asthma is a chronic airways disease, driven by inflammation and characterized by bronchial hyperresponsiveness and reversible expiratory flow limitation [1].

Mechanisms and therapeutic strategies for non‐T2 asthma

Non-T2 asthma is traditionally defined as asthma without features of T2 asthma. The definition is arbitrary and is generally based on the presence of ...