Uncovering Caffeine's Adenosine A2A Receptor Inverse Agonism in ...

Here we show that caffeine is an A2AR inverse agonist in cell-based functional studies and in experimental parkinsonism. Thus, we observed that caffeine ...

Uncovering caffeine's adenosine A2A receptor inverse agonism in ...

Caffeine, the most consumed psychoactive substance worldwide, may have beneficial effects on Parkinson's disease (PD) therapy.

The mechanism by which caffeine contributes to its antiparkinsonian effects by acting as either an adenosine A2A receptor (A2AR) neutral ...

Uncovering Caffeine's Adenosine A2A Receptor Inverse Agonism in ...

Here we show that caffeine is an A2AR inverse agonist in cell-based functional studies and in experimental parkinsonism. Thus, we observed that ...

Uncovering caffeine's adenosine A2A receptor inverse agonism in ...

Uncovering caffeine's adenosine A2A receptor inverse agonism in experimental parkinsonism. by Víctor Fernández-Dueñas, Maricel Gómez-Soler, Marc López-Cano, ...

Uncovering Caffeine's Adenosine A 2A Receptor Inverse Agonism in ...

The mechanism by which caffeine contributes to its antiparkinsonian effects by acting as either an adenosine A2A receptor (A2AR) neutral ...

Uncovering Caffeine's Adenosine A2A Receptor Inverse ... - Altmetric

Uncovering Caffeine's Adenosine A2A Receptor Inverse Agonism in Experimental Parkinsonism. Overview of attention for article published in ACS Chemical ...

Uncovering Caffeine's Adenosine A2A Receptor Inverse Agonism in ...

Uncovering Caffeine's Adenosine A2A Receptor Inverse Agonism in Experimental Parkinsonism ... Caffeine, the most consumed psychoactive substance worldwide, may ...

Adenosine A2A receptor antagonists: from caffeine to selective non ...

Adenosine is a short-lived autocrine/paracrine mediator that acts pharmacologically at four different adenosine receptors in a manner opposite to the pan- ...

Do caffeine and more selective adenosine A2A receptor antagonists ...

Large epidemiological studies have long shown caffeine consumption is a strong inverse predictor of Parkinson's disease (PD). In this review, we first examine ...

Uncovering Caffeine's Adenosine A2A Receptor Inverse Agonism in ...

Uncovering Caffeine's Adenosine A2A Receptor Inverse Agonism in Experimental Parkinsonism ; Mentioned by. twitter: 24 X users ; Citations. dimensions_citation: 40 ...

A2A adenosine receptor agonists, antagonists, inverse agonists and ...

Adenosine receptors (ARs) have been explored extensively as pharmaceutical targets since the late 1960s (IJzerman et al., 2022, Jacobson and Gao, 2006).

Pathways and Mechanism of Caffeine Binding to Human Adenosine ...

However, the pathways and mechanism of CFF binding to the target receptors remain unclear. In this study, we have performed all-atom-enhanced ...

Structure of the Adenosine A2A Receptor in Complex ... - Cell Press

caffeine, as well as the A2A selective inverse agonist. ZM241385. The receptor is crystallized in the inactive state conformation as defined ...

Allosteric interactions between agonists and antagonists within the ...

The adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R) heteromer is a target for the nonselective adenosine receptor antagonist caffeine. This study ...

Caffeinated clues and the promise of adenosine A2A antagonists in ...

The demonstration of a plausible receptor-based mechanism of action bolsters further a potential neuroprotective effect of caffeine in PD. Figure 2. Brain ...

Adenosine A2A receptor antagonist - Wikipedia

Notable adenosine A2A receptor antagonists include caffeine, theophylline and istradefylline.

A2A adenosine receptor agonists, antagonists, inverse ... - OUCI

A2A adenosine receptor agonists, antagonists, inverse agonists and partial agonists ... Fernández-Dueñas, Uncovering caffeine's adenosine A2A receptor inverse ...

The Pharmacological Potential of Adenosine A2A Receptor ... - MDPI

The potential for the use of adenosine antagonists in controlling disturbances in the sleep–wake cycle is shown by looking at the arousal effects of caffeine, a ...

Neuroprotection by Caffeine and A2A Adenosine Receptor ...

A2A adenosine receptors (A2ARs) may be particularly relevant because their expression in brain is largely restricted to the striatum (Sven- ningsson et al., ...