Understanding and targeting resistance mechanisms in cancer

Resistance to cancer therapies has been a commonly observed phenomenon in clinical practice, which is one of the major causes of treatment ...

Understanding and targeting resistance mechanisms in cancer - PMC

The present article focuses on the different mechanisms of drug resistance in cancer and the corresponding tackling approaches with recent updates.

Understanding and targeting resistance mechanisms in cancer - Lei

The reduced responsiveness of cancer cells can be associated with various mechanisms, including drug inactivation, reduced intracellular ...

Understanding and targeting resistance mechanisms in NSCLC

On-target resistance occurs when the primary target of the drug is altered, limiting the drug's ability to inhibit the activity of its target.

(PDF) Understanding and targeting resistance mechanisms in cancer

Alteration of drug target and activation of compensating pathways.

Understanding and targeting resistance mechanisms in NSCLC

Common mechanistic themes underpinning resistance to targeted therapies that are shared by NSCLC subtypes are highlighted, including those with oncogenic ...

final report of MATCH-R study with a focus on molecular drivers and ...

Understanding the resistance mechanisms of tumor is crucial for advancing cancer therapies. The prospective MATCH-R trial (NCT02517892), ...

Understanding and targeting resistance mechanisms in NSCLC.

The expanding spectrum of both established and candidate oncogenic driver mutations identified in non-small-cell lung cancer (NSCLC), coupled with the ...

Multidrug Resistance in Cancer: Understanding Molecular ...

The mechanism of MDR may also be mediated by the release of drugs outside of the cells. MDR may develop due to oncogene mutations, changes in the tumor ...

Mechanisms and recent breakthrough in targeted drug delivery

Cancer growth can provoke noncellular antineoplastic agent resistance in vivo. This phenomenon is typically correlated with solid malignancies, ...

Targeted Therapy for Cancer - NCI

Cancer cells can become resistant to targeted therapy. Resistance can happen when the target itself changes and the targeted therapy is not able ...

Understanding and targeting resistance mechanisms in NSCLC

It is likely that cancers intrinsically sensitive to anti-tumor therapy themselves contain at least one resistant subclone by genetic and/or ...

Mechanisms of resistance to targeted therapy and immunotherapy in ...

Promising strategies for overcoming resistance include the development of combination therapies, understanding the resistance mechanisms to better use novel ...

Drug resistance to targeted therapeutic strategies in non-small cell ...

In this review, we discuss two different resistance mechanisms in NSCLC targeted therapies, namely changes in the targeted oncogenes (on-target resistance)

Unveiling the mechanisms and challenges of cancer drug resistance

Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer treatment strategies are evolving due to innate and ...

Hallmarks of cancer resistance: iScience - Cell Press

Cancer resistance represents a multifaceted spectrum of mechanisms that enable malignant cells to withstand even the most potent therapeutic ...

DRMref: comprehensive reference map of drug resistance ...

Drug resistance poses a significant challenge in cancer treatment. Despite the initial effectiveness of therapies such as chemotherapy, targeted ...

Targeted Therapy and Mechanisms of Drug Resistance in Breast ...

In cancer, drug resistance is responsible for up to 90% of deaths [3]. Multidrug resistance (MDR) hinders the efficacy of chemotherapeutic drugs, often leading ...

Preventing Resistance to Cancer Targeted Therapies - NCI

Disrupting a specific process in cells, called non-homologous end-joining (NHEJ), may prevent tumors from becoming resistant to targeted ...

Strategic Combinations to Prevent and Overcome Resistance to ...

One of the most notable and well-studied mechanisms of adaptive resistance involves feedback reactivation of the RAS-MAPK pathway. Our understanding of the ...