Unfolded protein response‐mediated modulation of ...

Unfolded protein response-mediated modulation of mesenchymal ...

The UPR is mediated through three primary pathways: activating transcription factor-6, inositol-requiring enzyme-1 (IRE1), and PKR-like endoplasmic reticulum ...

Unfolded protein response‐mediated modulation of mesenchymal ...

The UPR is mediated through three primary pathways: activating transcription factor-6, inositol-requiring enzyme-1 (IRE1), and PKR-like endoplasmic reticulum ...

Unfolded protein response‐mediated modulation of mesenchymal ...

The present review aimed to explore and discuss the effects of the UPR pathways on mesenchymal stem cells.

Mechanism, regulation and functions of the unfolded protein response

ER proteostasis surveillance is mediated by the unfolded protein response (UPR), a signal transduction pathway that senses the fidelity of protein folding in ...

Modulation of the Unfolded Protein Response by the Severe Acute ...

ER stress induces three major pathways of the UPR signaling that are mediated through PERK kinase, IRE1, and ATF6, respectively (43). The phosphorylation of ...

CRISPR-Cas-mediated unfolded protein response control ... - Frontiers

To address ER stress, eukaryotic cells activate a series of compensatory adaptive mechanisms, collectively called the unfolded protein response (UPR) (Kozutsumi ...

Unfolded Protein Response - an overview | ScienceDirect Topics

(C) The PERK, ATF6 and IRE-1 branches of the UPR each mediate the transcriptional induction of ER stress response genes via the transcription factors, ATF4, ...

Endoplasmic reticulum unfolded protein response transcriptional ...

Additionally, we showed functional ERAD via sel-11 is required for XBP-1s-mediated tauopathy suppression in C. elegans. Because the two main ...

PERK mediates cell-cycle exit during the mammalian unfolded ...

Although it seems clear that Ire1 molecules and PERK modulate distinct components of the UPR, the events downstream of these ER kinases and their precise roles ...

The Unfolded Protein Response Mediates Adaptation to Exercise in ...

These findings suggest that modulation of the UPR through PGC1α represents an alternative avenue to improve skeletal muscle function and achieve ...

The unfolded protein response modulators GSK2606414 and KIRA6 ...

IRE1, PERK, and ATF6 are the three transducers of the mammalian canonical unfolded protein response (UPR). GSK2606414 is a potent inhibitor ...

Coronavirus Infection Modulates the Unfolded Protein Response ...

... modulate UPR-mediated events. To this end, MHV offers a tractable model to further investigate how viruses might abrogate UPR-regulated gene expression and ...

The Unfolded Protein Response: Integrating Stress Signals Through ...

In yeast, the UPR is controlled by only one signaling pathway, mediated by a type I transmembrane ER protein known as IRE1p (inositol-requiring transmembrane ...

Unfolded protein response (UPR) integrated signaling networks ...

HIFs mediate both the adaptive and apoptotic responses to hypoxia through transcriptional modulation of genes containing their specific ...

The Unfolded Protein Response in Immune Cells as an Emerging ...

PERK, on the other hand, mediates protein translation shutdown via phosphorylation of eukaryotic initiation factor-2α (p-eIF2α), which favors selective ...

VMP1 affects endoplasmic reticulum stress sensitivity via differential ...

Precise modulation of the UPR intensity remains a challenge in combating ER-stress-related diseases. Our study of VMP1-mediated fine-tuning of ...

Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded ...

The proteins are physically interacted with certain UPR components, being tightly modulated by action of each branch on different levels. For example, upon ...

Unfolded protein response‐mediated modulation of mesenchymal ...

The present review aimed to explore and discuss the effects of the UPR pathways on mesenchymal stem cells, which can be both cytoprotective and/or cytotoxic ...

Modulation of SARS-CoV-2 Spike-induced Unfolded Protein ...

However, the specific UPR pathway activated to mediate autophagic activities, and whether cytoprotective autophagy or autophagic cell death is ...

Unfolded protein response‐mediated modulation of mesenchymal ...

Request PDF | Unfolded protein response‐mediated modulation of mesenchymal stem cells | The endoplasmic reticulum (ER) receives unfolded proteins ...