Unfolded protein response‐mediated modulation of mesenchymal ...

Unfolded protein response-mediated modulation of mesenchymal ...

The UPR is mediated through three primary pathways: activating transcription factor-6, inositol-requiring enzyme-1 (IRE1), and PKR-like endoplasmic reticulum ...

The present review aimed to explore and discuss the effects of the UPR pathways on mesenchymal stem cells.

Unfolded protein response‐mediated modulation of ... - UQ eSpace

Unfolded protein response-mediated modulation of mesenchymal stem cells. Fataneh Tavasolian. 1,2,. Ahmad Zavaran Hosseini. 3. , Ali Mirzaei. 4,5. , Elham ...

Unfolded protein response‐mediated modulation of mesenchymal ...

The present review aimed to explore and discuss the effects of the UPR pathways on mesenchymal stem cells, which can be both cytoprotective and/or cytotoxic ...

Unfolded protein response‐mediated modulation of mesenchymal ...

Request PDF | Unfolded protein response‐mediated modulation of mesenchymal stem cells | The endoplasmic reticulum (ER) receives unfolded proteins ...

New insights into the unfolded protein response in stem cells - PMC

Therefore, ER stress-associated apoptosis is involved in mesenchymal stem cell apoptosis [166-168]. GRP78 regulates ER stress-mediated apoptosis in cartilage ...

Mesenchymal stromal cells modulate unfolded protein response and ...

Our findings reveal that MSCs infusion does not alleviate endoplasmic reticulum stress in β cells directly but modulates the unfolded protein response pathway.

Unfolded protein response‐mediated modulation of mesenchymal ...

AbstractThe endoplasmic reticulum (ER) receives unfolded proteins predestined for the secretory pathway or to be incorporated as transmembrane proteins.

New insights into the unfolded protein response in stem cells

Unfolded protein response‐mediated modulation of mesenchymal stem cells · F. TavasolianA. Hosseini +8 authors. A. Sahebkar. Medicine, Biology. IUBMB life. 2019.

A bird's eye view of mitochondrial unfolded protein response in cancer

Recent studies have shown that UPR mt is dysregulated in various cancers and contributes to tumor initiation, growth, metastasis, and therapeutic resistance.

The roles of ER stress and the UPR in stem cells. The activation of ...

54 ... Unfolded protein response‐mediated modulation of mesenchymal stem cells. Article. Aug 2019; IUBMB LIFE. Fataneh Tavasolian ...

Mesenchymal Stem Cell-Derived Extracellular Vesicles Protect ...

... proteins, thus inducing misfolded proteins and an unfolded protein response [25]. ... mesenchymal stromal cells modulate miRNA in renal ...

Endoplasmic reticulum stress: molecular mechanism and ... - Nature

Also, prolonged UPR affects protein synthesis, which further aggravates the ERAD deficiency. ER stress can modulate the phosphorylation of eIF2α ...

The Role of Endoplasmic Reticulum Stress in Differentiation of Cells ...

In this article, we reviewed the data on the role of ER stress and UPR in the differentiation of cells of mesenchymal origin, namely, ...

The Unfolded Protein Response at the Tumor-Immune Interface

... Unfolded Protein Response in Tumor Cells Modulate the Immunological Landscape of the Tumor Microenvironment. ... A PQM-1-Mediated Response Triggers ...

Unfolded protein response in colorectal cancer - Cell & Bioscience

In mammals, the UPR signal pathway is mediated by three ER transmembrane protein sensors: inositol requiring kinase 1 (IRE1), pancreatic ER ...

PERK, Beyond an Unfolded Protein Response Sensor in Estrogen ...

The unfolded protein response (UPR) is initiated by E2 in the endoplasmic reticulum after hours of treatment in endocrine-resistant breast cancer cells, thereby ...

Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded ...

The proteins are physically interacted with certain UPR components, being tightly modulated by action of each branch on different levels. For example, upon ...

Endoplasmic reticulum-mediated unfolded protein response and ...

In turn, these changes modulate overall cellular physiology by impacting cellular bioenergetics as well as the apoptosis potential in response to stress [37].

Endoplasmic Reticulum Stress in Disease Pathogenesis

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2α. ... Proapoptotic BAX and BAK modulate the ...