Unfolded protein response IRE1/XBP1 signaling is required for ...

Aging is a major risk factor to develop neurodegenerative diseases and is associated with decreased buffering capacity of the proteostasis ...

Synopsis. image. The UPR pathway sustains brain function, delaying the natural appearance of age‐associated phenotypes in mammals. IRE1/XBP1 signaling improves ...

Unfolded protein response IRE1/XBP1 signaling is required for ...

We investigated the significance of the unfolded protein response (UPR), a major signaling pathway activated to cope with endoplasmic reticulum (ER) stress, in ...

Unfolded protein response IRE1/XBP1 signaling is required for ...

Genetic ... [Show full abstract] disruption of ER stress sensor IRE1α accelerated cognitive and motor dysfunction during aging. Exogenous ...

Unfolded protein response IRE1/XBP1 signaling is required for ...

Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging. The EMBO journal (2022-11-01). Felipe Cabral-Miranda, Giovanni ...

Xbp1-Independent Ire1 Signaling Is Required for Photoreceptor ...

The unfolded protein response (UPR) is composed by homeostatic signaling pathways that are activated by excessive protein misfolding in the ...

The requirement of IRE1 and XBP1 in resolving physiological stress ...

IRE1 mediates the unfolded protein response (UPR) in part by regulating XBP1 mRNA splicing in response to endoplasmic reticulum (ER) stress.

Unfolded protein response transducer IRE1-mediated signaling ...

The unfolded protein response sensor/transducer IRE1-mediated splicing of XBP1 mRNA encoding its active downstream transcription factor to ...

IRE1/XBP1 and endoplasmic reticulum signaling - ScienceDirect.com

Recent studies have defined notable functions for the inositol-requiring kinase 1 (IRE1)/X-box- binding protein-1 (XBP1) branch of the UPR in ...

IRE1 signaling increases PERK expression during chronic ER stress

The Unfolded Protein Response (UPR) is an essential cellular process activated by the accumulation of unfolded proteins within the ...

Disclosing the role of XBP1s in Alzheimer's disease - Cell Press

XBP1 is a master regulator of the unfolded protein response (UPR) and its overexpression in the central nervous system ameliorates Aβ burden, ...

The IRE1/XBP1 signaling axis promotes skeletal muscle ... - eLife

However, the role of individual arms of the UPR in skeletal muscle regeneration remain less understood. In the present study, we demonstrate ...

The unfolded protein response transcription factor XBP1s ...

Inositol-requiring enzyme-1 (IRE1) operates as a central ER stress sensor, enabling the establishment of adaptive and repair programs through ...

The Unfolded Protein Response: Integrating Stress Signals Through ...

Inositol-requiring transmembrane kinase/endonuclease-1 (IRE1α), the most conserved UPR stress sensor, functions as an endoribonuclease that processes the mRNA ...

IRE1β negatively regulates IRE1α signaling in response to ...

Our cell and biochemical data show that IRE1β dampens the UPR to ER stress. IRE1β restricts ER stress–induced IRE1α endonuclease activity, as ...

Orchestrating the unfolded protein response in health and disease

Transcription of UPR-responsive genes is induced when the cleaved form of ATF6 activates the XBP1 promoter. Therefore, signaling through ATF6 and IRE1 merges to ...

The unfolded protein response in metazoan development

The physiological importance of the IRE1–XBP1 axis has been further validated in Drosophila, frogs and fish. In Drosophila, Ire1 and Xbp1 ...

IRE1-XBP1 Pathway of the Unfolded Protein Response Is Required ...

In skeletal muscle, myoblast differentiation results in the formation of multinucleated myofibers. Although recent studies have shown that unfolded protein ...

Unfolded protein response IRE1/XBP1 signaling is required for ...

Huella. Profundice en los temas de investigación de 'Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging ...

Neuronal activity‐dependent local activation of dendritic unfolded ...

To explore the roles of UPR signaling in neurons, we focused on the dendritic roles of the IRE1-XBP1 branch, because of previous studies that ...