Universal redirection of CAR T cells against solid tumours via ...

The effectiveness of chimaeric antigen receptor (CAR) T cell therapies for solid tumours is hindered by difficulties in the selection of an ...

Universal redirection of CAR T cells against solid tumours ... - PubMed

The effectiveness of chimaeric antigen receptor (CAR) T cell therapies for solid tumours is hindered by difficulties in the selection of an effective target ...

Abstract 1149: Universal redirection of chimeric antigen receptor T ...

Chimeric antigen receptor (CAR) T cell therapy is effective in treating certain hematological malignancies, but its translation to solid ...

(PDF) Universal redirection of CAR T cells against solid tumours via ...

Chimeric antigen receptor (CAR) T cell therapy effectively treats human cancer, but the loss of the antigen recognized by the CAR poses a major ...

In situ antigen modification-based target-redirected universal ...

Background: Chimeric antigen receptor (CAR)-T cell therapy has demonstrated remarkable success in the treatment of hematologic malignancies, ...

Antibody-based redirection of universal Fabrack-CAR T cells ...

Background Chimeric antigen receptor (CAR) T cells engineered to recognize and target tumor associated antigens have made a profound impact on the quality ...

In situ antigen modification-based target-redirected universal ...

Chimeric antigen receptor (CAR)-T cell therapy has demonstrated remarkable success in the treatment of hematologic malignancies, while the ...

Redirecting CAR T-Cell Specificity with A Universal and Adaptable ...

Using a bispecific antibody, tumor cells expressing a TAA can be targeted via the adapter bispecific. This bispecific adapter molecule then ...

Engineering enhanced chimeric antigen receptor-T cell therapy for ...

Single-gene perturbations for improving solid tumor CAR-T mainly include enhancing or silencing various transcription factors.

CAR-cell therapy in the era of solid tumor treatment

In the last decade, Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a promising immunotherapeutic approach to fight cancers.

Directing CAR T cells towards the tumor vasculature for the ...

C) CAR T cells targeting solid tumors through targeting the tumor vasculature. CAR T cells can directly engage with tumor endothelial cells from within the ...

Identification of Targets to Redirect CAR T Cells in Glioblastoma and ...

When expressed by T cells, the CAR enables the recognition and subsequent destruction of cancer cells expressing the complementary antigen on their surface.

[PDF] Universal redirection of CAR T cells against solid tumours via ...

It is shown that T cells with a CAR specific for fluorescein isothiocyanate (FITC) can be directed against solid tumours via the intratumoural ...

Probiotic-guided CAR-T cells for solid tumor targeting - Science

A major challenge facing tumor-antigen targeting therapies such as chimeric antigen receptor (CAR)–T cells is the identification of suitable ...

Engineering strategies to overcome the current roadblocks in CAR T ...

Antigens expressed at higher levels on tumour cells than on non-malignant cells could potentially be targeted using lower-affinity scFv CARs, ...

of Genetically Engineered CAR-T Cells Using Bifunctional Small ...

Anti-FITC-CAR-T cell activation and proliferation was strictly dependent on the presence of both folate-FITC and FR-positive cells and was dose ...

Universal redirection of CAR T cells against solid tumours via ... - OUCI

AbstractThe effectiveness of chimaeric antigen receptor (CAR) T cell therapies for solid tumours is hindered by difficulties in the selection of an ...

Car T Cells in Solid Tumors: Overcoming Obstacles - MDPI

In this approach, T lymphocytes are genetically modified to express a chimeric antigen receptor (CAR) based on the antibody structure [14]. In this regard, ...

Enhancing CAR T-cell therapies against solid tumors - Frontiers

VEGF is a cytokine important for angiogenesis of tumor cells. T-cells expressing anti-VEGF2 CARs inhibit multiple types of syngeneic tumors through increased ...

Hung Trinh on LinkedIn: Universal redirection of CAR T cells against ...

Universal redirection of CAR T cells against solid tumours via membrane-inserted ligands for the CAR The effectiveness of chimaeric antigen receptor (CAR) ...