University of Dundee The role of O|GlcNAcylation in development ...

The role of O-GlcNAcylation in development - PubMed

O-GlcNAcylation is a dynamic post-translational modification performed by two opposing enzymes: O-GlcNAc transferase and O-GlcNAcase.

University of Dundee The role of O-GlcNAcylation in development ...

ABSTRACT. O-GlcNAcylation is a dynamic post-translational modification performed by two opposing enzymes: O-GlcNAc transferase and. O-GlcNAcase.

The role of O-GlcNAcylation in development - ResearchGate

O-GlcNAcylation is a dynamic post-translational modification performed by two opposing enzymes: O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation is ...

Deciphering the role of O-GlcNAcylation in neuronal development ...

O-GlcNAcylation is an essential intracellular protein modification mediated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). This modification occurs on ...

The role of O-GlcNAcylation in development – Projects — Discovery ...

The role of O-GlcNAcylation in development. Ignacy ... O-GlcNAc Transferase ... Discovery - the University of Dundee Research Portal data protection policy.

Genetic recoding to dissect the roles of site-specific protein O ...

School of Life Sciences, University of Dundee, Dundee, UK. 6. 7 ... A mutant O-GlcNAcase enriches Drosophila developmental regulators. Nat Chem. 276. Biol ...

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell ...

Division of Cell Signalling and Immunology, University of Dundee, United Kingdom. ... O-GlcNAcylation at key stages of development in the thymus, following ...

Dundee scientists probe healthy protein enzyme process - BBC News

O-GlcNAc is essential for human function, but also affects the development of diseases such as cancer, diabetes and dementia. Prof Aalten added: ...

Tools for functional dissection of site-specific O-GlcNAcylation

Modification of proteins with O-GlcNAc is required for metazoan embryo development and maintains cellular homeostasis through effects on ...

The role of O-GlcNAcylation in development

of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. 2Institute of. Molecular Precision Medicine, Xiangya Hospital, Central South University,. Changsha ...

Investigating the role of UDP-N-acetylhexosamine ...

O-GlcNAcylation has been found to modulate enzyme catalytic activity, protein stability, protein–protein interaction and protein subcellular localisation.

Reductionist animal models to probe protein O-GlcNAcylation

Protein O-GlcNAcylation is a reversible type of glycosylation of serine and threonine residues of nucleocytoplasmic proteins occurring in all animals examined ...

Genetic encoding of a stable O-GlcNAc analogue — Discovery

Attachment of N-acetylglucosamine to hydroxyl groups of serine and threonine residues of intracellular proteins is known as O-GlcNAcylation, an essential ...

Dundee scientists probe healthy protein enzyme process - BBC News

O-GlcNAc is essential for human function, but also affects the development of diseases such as cancer, diabetes and dementia. Prof Aalten added: ...

Deciphering the causes and effects of O-GlcNAc Transferase ...

Among the several forms of glycosylation, the addition of a single moiety of O-linked N-acetylglucosamine (O-GlcNAc) stands out for its uniqueness. This highly ...

The development of Geography as a university subject in Dundee

In 2010 Allan Findlay and Alan Werrity published an article opening a special issue of the Scottish Geographical Journal (SGJ) celebrating ...

Catalytic deficiency of O-GlcNAc transferase leads to X-linked ...

Genetic studies have highlighted the importance of OGT and protein O-GlcNAcylation in development. OGT is essential for embryonic stem cell viability (19, 20) ...

Intellectual disability-associated disruption of O-GlcNAc cycling ...

This study establishes a critical role for O-GlcNAc cycling and disrupted O-GlcNAc transferase activity in cognitive dysfunction.

Modelling O-GlcNAc transferase intellectual disability syndrome in ...

Transgenic animals can also be used to determine the role of O-GlcNAc at specific amino acid sites, which can require a large number of animals to successfully ...

Ignacy CZAJEWSKI | Division of Cell and Developmental Biology

O-GlcNAcylation is an essential intracellular protein modification mediated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Recently, missense mutations in ...