Unveiling the therapeutic promise of EphA2 in glioblastoma

In this review, we aim to provide a comprehensive overview of the important roles of EphA2 in GBM development and treatment.

(PDF) Unveiling the therapeutic promise of EphA2 in glioblastoma

associated with EphA2-directed interventions in the domain of cancer therapeutics. Keywords EphA2 · Receptor tyrosine kinase · Noncanonical ...

Unveiling the therapeutic promise of EphA2 in glioblastoma: a ... - BVS

Glioblastoma (GBM), a primary brain tumor, exhibits remarkable invasiveness and is characterized by its intricate location, infiltrative behavior, ...

Unveiling the therapeutic promise of EphA2 in glioblastoma: a ...

Zantek ND, Azimi M, Fedor-Chaiken M, Wang B, Brackenbury R, Kinch MS. E-cadherin regulates the function of the EphA2 receptor tyrosine kinase. Cell Growth ...

Unveiling the therapeutic promise of EphA2 in glioblastoma

Unveiling the therapeutic promise of EphA2 in glioblastoma: a comprehensive review. Caohang Qiu. Ning Sun. Shan Zeng. Ligang Chen. Feilong Gong.

Unveiling the therapeutic promise of EphA2 in glioblastoma: a ...

... Unveiling the therapeutic promise of EphA2 in glioblastoma: a comprehensive review. Dolecek TA, Propp JM, Stroup NE, Kruchko C. CBTRUS statistical report ...

Oncogenic Functions and Therapeutic Targeting of EphA2 in Cancer

This review will summarize pre-clinical studies supporting the oncogenic role of EphA2 in breast cancer, lung cancer, glioblastoma, and melanoma.

EphA2 Promotes Infiltrative Invasion of Glioma Stem Cells in vivo ...

Unveiling the therapeutic promise of EphA2 in glioblastoma: a comprehensive review. Article. Full-text available. Sep 2024. Caohang Qiu · Ning Sun · Shan Zeng ...

Emerging strategies for EphA2 receptor targeting for cancer ...

EphA2 overexpression is observed in several glioblastoma multiforme (GBM)- ... EphA2 as a target for therapeutic drug delivery. Biodegradable nanoparticles ...

Unveiling the therapeutic potential of IHMT-337 in glioma treatment

This compound has shown promise in clinical applications by ... EPHA2 mediates PDGFA activity and functions together with PDGFRA as ...

EphA2: A promising therapeutic target in breast cancer.

Unveiling the therapeutic promise of EphA2 in glioblastoma: a comprehensive review ... EphA2-ephrin A1 signaling axis in GBM pathogenesis is provided.

Citations to The receptor tyrosine kinase EphA2 promotes ... - JCI

Unveiling the therapeutic promise of EphA2 in glioblastoma: a comprehensive review. Qiu C, Sun N, Zeng S, Chen L, Gong F, Tian J, Xiong Y, Peng L, He H, Ming Y ...

Antitumor activity of the third generation EphA2 CAR-T cells against ...

To reveal the mechanism of differentially expressed genes in these two EphA2 ... EphA2-CAR-T cell therapy against GBM ( Figure 8 ). Figure 8 ...

First-in-Human Trial of EphA2-Redirected CAR T-Cells in Patients ...

Glioblastoma is the most common primary brain malignancy with limited treatment options. EphA2 is a tumor-associated-antigen overexpressed ...

Citations to The receptor tyrosine kinase EphA2 promotes ... - JCI

Unveiling the therapeutic promise of EphA2 in glioblastoma: a comprehensive review. Qiu C, Sun N, Zeng S, Chen L, Gong F, Tian J, Xiong Y, Peng L, He H, Ming ...

Therapy for glioblastoma: is it working? - ScienceDirect.com

... reveal itself, as the results of ongoing and future GBM trials become available. ... The use of optimised drugs in combination also holds considerable promise ...

Dimeric small molecule agonists of EphA2 receptor inhibit ... - OUCI

Unveiling the therapeutic promise of EphA2 in glioblastoma: a comprehensive review. Caohang Qiu, Ning Sun, Shan Zeng, Ligang Chen, Feilong Gong, Junjie Tian ...

Molecular targeted therapy: A new avenue in glioblastoma treatment ...

... reveal the effectiveness of the combined treatment. There are ... glioblastoma: The promise of combination strategies. J Exp Clin ...

Treatment advances in high-grade gliomas - Frontiers

While CAR-T therapy shows promise in glioma treatment, it has been observed ... T cells redirected to EphA2 for the immunotherapy of glioblastoma. Mol ...

Understanding the immunosuppressive microenvironment of glioma

Targeting EPHA2 with CAR-T therapy can facilitate ... Vaccine therapy for GBM holds promise in preclinical and early clinical assessments.