Updates in the genomics of SMM

Updates in the genomics of SMM & multiple myeloma | VJHemOnc

In this session chaired by Leif Bergsagel, MD, Mayo Clinic, Phoenix, AZ, Francesco Maura, MD, Sylvester Comprehensive Cancer Center, ...

The genomic profiling of high-risk smoldering myeloma patients ...

However, the usefulness of such markers in the context of clinical trials evaluating upfront treatment in high-risk SMM (HR SMM) has not been ...

Genomic Profiling of Smoldering Multiple Myeloma Identifies ...

Results: We observed that most of the genetic alterations necessary for progression have already been acquired by the diagnosis of SMM. ... We validated these ...

Genomics of Smoldering Multiple Myeloma: Time for Clinical ...

... SMM but having a ≥80% risk of progression within two years. Despite this update, SMM remains a clinically defined entity characterized by a ...

Genomic Profiling to Interpret the Outcomes of Early Intervention for ...

In patients treated on 2 parallel clinical trials for HR-SMM, we found a uniform and relative genomic simplicity. Moreover, non-progressors ...

SMM & MGUS: clinical relevance, the PROMISE study & the role of ...

Trial Updates · AI in HemOnc · View all Topics ... IBC 2024 | SMM & MGUS: clinical relevance, the PROMISE study & the role of genomics.

Using genomics to better define high-risk MGUS/SMM patients - PMC

Instead a careful “watch and wait” strategy is employed in which patients are monitored for signs of MM progression. These new NGS studies illustrate that PCs ...

Telo Genomics Reports Substantial Progress Toward Clinical ...

(TSXV: TELO) (OTCQB: TDSGF) (the "Company" or "Telo") is pleased to provide an update on the planned launch of the TeloView®SMM (Smoldering ...

PROMISE Update: genomic alterations in MGUS and SMM - YouTube

Irene Ghobrial, MD, Dana-Farber Cancer Institute, Boston, MA, gives an update on the PROMISE study (NCT03689595) which aimed to determine ...

Abstract 2240: Genomic profiling of smoldering multiple myeloma ...

SMM patients have a 10% annual risk of progression to MM. Genomic alterations that are observed in SMM patients include chromosomal gains and ...

Genomic patterns of progression in smoldering multiple myeloma

... (SMM) is a premalignant stage of multiple myeloma (MM). Here the authors perform whole genome sequencing of unique paired samples of SMM ...

Genomic Features Associated With Higher Risk of Progression in ...

Bustoros:The genomic profiling can improve the SMM stratification by incorporating these panels that can now be used in the clinical setting. By ...

Multiple myeloma progression: largest genome sequencing project ...

Mark Bustoros, a member of the research team, explained: “We found that mutations were more frequent in the high-risk group of patients with SMM ...

Some with Smoldering Multiple Myeloma May Benefit from Prompt...

“Our study shows, however, when the disease follows the static progression model, SMM is, from a genomic standpoint, myeloma. The advance of ...

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S0120 G.E.M.S.: genomics encounters MGUS and SMM | Blood

Since ∼30% of genes in the GEP-70 score are from chromosome 1, this part of the S0120 data is concordant with the FISH data that demonstrated ...

News - Icahn School of Medicine at Mount Sinai

Crystal Professor and Chair of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai, has been selected as the first female recipient of ...

Human Genomics: Home page

... social media. ... This Collection contains all previously published Gene Family Updates and will continue to include any new Gene Family Updates that publish.

BeginNGS News Updates | RCIGM

In the News · International Newborn Genome Sequencing Projects Discuss Differences, Future Goals · Rare Community Profiles: Inozyme's Catherine Nester Discusses ...

The Advances in Social Genomics Conference

Social genomics researchers from across the world convene at the University of Wisconsin–Madison each year to discuss advances in the field.