Using Circulating Tumor DNA in Colorectal Cancer

ctDNA has emerged as a powerful biomarker predicting which patients with CRC are likely to relapse on the basis of an occult or persistent state of disease (Fig ...

Using Circulating Tumor DNA in Colorectal Cancer: Current and ...

Circulating tumor DNA (ctDNA) has emerged as a promising prognostic and possibly predictive biomarker in the personalized management of patients ...

Using Circulating Tumor DNA in Colorectal Cancer - PubMed

There exists a tremendous opportunity in identifying and determining the appropriate predictive and prognostic biomarker(s) for risk ...

ctDNA May Guide Who Needs Chemo After Colorectal Cancer Surgery

By looking for fragments of DNA that have escaped from tumors into the bloodstream, or circulating tumor DNA (ctDNA), doctors may be able to ...

Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage ...

A ctDNA-guided approach to the treatment of stage II colon cancer reduced adjuvant chemotherapy use without compromising recurrence-free survival.

Studies Show Progress in Using ctDNA to Guide Colorectal Cancer ...

We found that ctDNA detection of MRD is a powerful prognostic and predictive tool in patients with stage II and III colorectal cancer.

Clinical application of circulating tumour DNA in colorectal cancer

Liquid biopsies that detect circulating tumour DNA (ctDNA) have the potential to revolutionise the personalised management of colorectal cancer.

Clinical impact of circulating tumor DNA to track minimal residual ...

ctDNA is a promising biomarker to select patients with resected colon cancer for adjuvant chemotherapy. •. ctDNA analysis methods should be chosen adequately to ...

ctDNA-based molecular residual disease and survival in resectable ...

The GALAXY study is designed to monitor ctDNA-based MRD status for patients with clinical stage II–IV or relapsed CRC after curative-intent ...

Clinical impact of circulating tumor DNA to track minimal residual ...

ctDNA is a promising biomarker to select patients with resected colon cancer for adjuvant chemotherapy. •. ctDNA analysis methods should be ...

Unraveling the potential clinical utility of circulating tumor DNA ...

Here, we used tumor-informed dPCR for ctDNA detection in a large colorectal cancer (CRC) cohort to evaluate the potential for post-operative ...

DNA Shed From Colon Cancers Into Bloodstream Guide ...

A new research study showed that circulating tumor DNA (ctDNA) — genetic material shed from tumors into the bloodstream — can identify stage II ...

circulating tumor DNA (ctDNA) - Know Your Biomarker

In cancer patients with stage IV / metastatic colorectal cancer (mCRC), measurement of the amount of ctDNA in blood before and during treatment can predict ...

Dynamic Monitoring of Circulating Tumor DNA in Patients With ...

Mutational analysis performed on ctDNA is useful for the molecular characterization of colorectal cancer. The study provides additional data on ...

Clinical application of circulating tumour DNA in colorectal cancer

ctDNA assessment can complement standard tissue-based testing for molecular characterisation, with the added ability to monitor emerging mutations under the ...

Colorectal Cancer Surveillance With Circulating Tumor DNA Assay

This retrospective, single-institution study reported on the results of surveillance of 48 patients with stage II to IV colorectal cancer who had completed ...

Circulating Tumor DNA in Precision Oncology and Its Applications in ...

Patients with certain types of solid tumors, including colorectal cancer (CRC), can have levels of cfDNA 50 times higher than healthy patients. ctDNA undergoes ...

ctDNA applications and integration in colorectal cancer: an NCI ...

An increasing number of studies are describing potential uses of circulating tumour DNA (ctDNA) in the care of patients with colorectal ...

Can Circulating Tumor DNA Predict Who Will Benefit from Colorectal ...

Researchers discovered that patients with high-risk stage II, stage III, and stage IV CRC, who were ctDNA-positive four weeks after surgery, ...

Circulating Tumor DNA and Management of Colorectal Cancer - MDPI

Osumi et al. evaluated 110 patients with metastatic CRC undergoing chemotherapy to evaluate the correlation between ctDNA and CEA. The overall concordance rate ...