Using JAX NSG ™ Mice to Test CAR T Therapy for Breast Cancer

Chimeric antigen receptor (CAR) T cell therapy represents the culmination of years of research in both immunology and oncology fields.

Using JAX NSG™ Mice to Test CAR T Therapy for Breast Cancer

NSG™ Mice Reveal the Effect of CAR T Therapy · Next-generation Drug Development Requires the Most Optimal Mouse Models.

CAR T cell therapy for breast cancer: harnessing the tumor milieu to ...

The adoptive transfer of T cells redirected to tumor via chimeric antigen receptors (CARs) has produced clinical benefits for the treatment ...

Immune-restoring CAR-T cells display antitumor activity and reverse ...

We tested CAR-T cells in a humanized clear cell renal cell carcinoma (ccRCC) orthotopic mouse model with reconstituted human leukocyte antigen (HLA) partially ...

Let's Talk Accelerating Development of CAR T Therapies (15Feb2022)

Helpful Resources: Blog: Using JAX NSG™ Mice to Test CAR T Therapy for Breast Cancer https://bit.ly/32LceXS Blog: CAR T Cell Therapy, Are We ...

Determining preclinical CAR T-cell persistence by flow cytometry

... T-cell therapies are often investigated using a mouse as the test subject ... measure human T cells in NSG mice over time is shown in Figure 2.

Stressed target cancer cells drive nongenetic reprogramming of ...

Chimeric antigen receptor T-cell therapy (CAR T) has achieved unprecedented success as a novel immunotherapy with curative potential for certain ...

Humanized Mice Are Precious Tools for Preclinical Evaluation of ...

About 10 years ago, a matched patient's tumor and T cells were engrafted in NSG mice to show the cancer patient's T cells can function as CAR T cells [60].

CD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 ...

Immunotherapies using Chimeric Antigen Receptor (CAR) T cells [13, 14] have shown extraordinary results in patients with B cell malignancies [15] ...

James KECK | The Jackson Laboratory, Bar Harbor | Research profile

Mouse models to assess efficacy and cytokine release associated with T cell engagement are needed. JAX humanized NOD scid gamma (Hu-NSG™) mice are engrafted ...

Humanized Mouse Models for Immuno‐oncology Drug Discovery

injection of tumor cells into hCD34+ HSC humanized NSG mice (Zhao et al., 2021) to create a more relevant TME for evaluation of human-specific ...

Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth

employed single-cell RNA sequencing (scRNA-seq) to delineate cell populations within CD45+ bone marrow cells of patients with RRMM both before ...

SGM3 Mice for Immuno-Oncology - CORE

Tumor-bearing, humanized NSG mice (the Onco-. Hu™* mouse offered exclusively from The Jackson. Laboratory) are a new and valuable preclinical testing platform ...

Multi-armored allogeneic MUC1 CAR T cells enhance efficacy and ...

Using a multi-layered CAR T cell engineering strategy that allowed a synergy between attributes, we show enhanced cytotoxic activity of MUC1 CAR ...

A humanized orthotopic mouse model for preclinical evaluation of ...

We demonstrated early and robust reconstitution of human CD45+ leukocytes including T cells, B cells, natural killer cells and monocytes. Ewing ...

Quiescent cancer cells resist T cell attack by forming an ...

We first tested the ability of surviving GFP+ cells to regrow tumors compared with that of bulk GFP cells. Jedi T cell-resistant GFP+ cells were ...

JAX® Mice, Clinical & Research Services

Humanized NSG™ (hu-NSG™) mice represent an · innovative and cost ... T cells and B cells with · improved class switching · and robust IgG production ...

Danying Cai's research works | The Jackson Laboratory and other ...

Here, we describe the development of PBMC humanized mouse model based on the NSG-MHC I/II-DKO strain to study autologous CD19 CAR-T treatment related tumor ...

Humanized Mouse Models for Immunotherapy Research

For instance, humanized NSG™ mice (huNSG, from The Jackson ... with test articles for combination therapy. However, you should not expect ...

Bispecific Adaptor Controlled CAR-T Therapy - Frontiers

... T cell activation and cytolytic activity with a low FR threshold against tumor targets. ... In tumor-bearing mice ... cell lung cancer, and triple-negative breast ...