Validation of the Surrogate Threshold Effect for Change in Bone ...

The surrogate threshold effect (STE) is defined as the minimum treatment effect on a surrogate that is reliably predictive of a treatment effect on the ...

The surrogate threshold effect (STE) is defined as the minimum treatment effect on a surrogate that is reliably predictive of a treatment ...

Validation of the Surrogate Threshold Effect for Change in BMD as a ...

Validation of the Surrogate Threshold Effect for Change in BMD as a Surrogate Endpoint for Fracture Outcomes: the FNIH-ASBMR SABRE Project.

Validation of the Surrogate Threshold Effect for Change in Bone ...

Validation of the Surrogate Threshold Effect for Change in Bone Mineral Density as a Surrogate Endpoint for Fracture Outcomes: The FNIH-ASBMR SABRE Project.

Validation of the Surrogate Threshold Effect for Change in BMD as a ...

It provides a framework for implementing a clinical trial with a surrogate endpoint. The aim of this study was to update our previous analysis ...

Validation of the Surrogate Threshold Effect for Change ... - Altmetric

Validation of the Surrogate Threshold Effect for Change in Bone Mineral Density as a Surrogate Endpoint for Fracture Outcomes: The FNIH‐ASBMR SABRE Project.

Is bone density a valid surrogate for fracture?

Through this relationship, one can quantify the effect of BMD change on fracture risk (the slope of the curve). ... What may affect the validity of BMD as a surro ...

Bone mineral density as a surrogate endpoint for fracture risk ...

Eastell, R ∙ Vittinghoff, E ∙ Lui, LY ∙ et al. Validation of the surrogate threshold effect for change in bone mineral density as a ...

relationship between treatment-related changes in total hip BMD ...

There is a strong association between total hip bone mineral density (THBMD) changes after 24 mo of treatment and reduced fracture risk. We examined whether ...

The validation of bone mineral density (BMD) as a surrogate outcome for fracture would allow the size of future randomised controlled ...

The validation of bone mineral density (BMD) as a surrogate outcome for fracture would allow the size of future randomised controlled osteoporosis ...

Bone mineral density as a surrogate endpoint for fracture risk ...

Validation of the Surrogate Threshold Effect for Change in BMD as a Surrogate Endpoint for Fracture Outcomes: the FNIH‐ASBMR SABRE Project.

Evidence-Based Guideline for the management of osteoporosis in ...

Validation of the surrogate threshold effect for change in bone mineral density as a surrogate endpoint for fracture outcomes: the FNIH ...

Romosozumab followed by denosumab versus denosumab only: a ...

, et al. Validation of the surrogate threshold effect for change in bone mineral density as a surrogate endpoint for fracture outcomes: the ...

Surrogate threshold effect: a novel approach for potential approval ...

Surrogate threshold effect: a novel approach for potential ... change in BMD. Study-level analysis from the FNIH Bone Quality Project.

Surrogate threshold effect based on a meta-analysis ... - SpringerLink

Hence a validation of PFS as surrogate endpoint for overall survival (OS) is needed, e.g., in the indication of HR+, HER2-negative mBC. Methods.

Burzykowski, Surrogate threshold effect: an alternative measure for meta-analytic surrogate endpoint validation, Pharm Stat, № 5, с. ... Liberman, Effect of oral ...

is bone density a valid surrogate for fracture? - Semantic Scholar

A review of definitions of surrogate endpoints and requirements for their statistical validation indicates that the actual BMD value is correlated with ...

What clinicians should know about surrogate end points in ...

As opposed to prognostic markers, surrogates are end points that can be measured earlier, easier, or with lower cost, and yet can still capture the full effect ...

WCO-IOF-ESCEO 2022 – Post-hoc analysis on the proportion ... - UCB

... bone mineral density (BMD) surrogate threshold effect (STE) required for any fracture risk reduction at 12 months. Over 55% of patients ...