When to believe a subgroup analysis

When to believe a subgroup analysis: revisiting the 11 criteria - Nature

Here, we revisit the 11 criteria (Table 1) introduced by Sun et al. [7] and provide literature case examples to illustrate important principles and concepts.

When to believe a subgroup analysis: revisiting the 11 criteria

When to believe a subgroup analysis: revisiting the 11 criteria.

Three simple rules to ensure reasonably credible subgroup analyses

Categorical subgroup analyses should not be part of a typical clinical trial's primary (hypothesis testing) analysis unless the prior ...

Debate: Subgroup analyses in clinical trials: fun to look at - PubMed

Plausible explanations can usually be found for effects that are, in reality, simply due to the play of chance. When clinicians believe such subgroup analyses, ...

Subgroup Analysis: Pitfalls, Promise, and Honesty - Marc Ratkovic

We are focused on inference, asking whether we can trust our confidence intervals from a subgroup analysis. The results are shown in Table 1 ...

When to believe a subgroup analysis: revisiting the 11 criteria

When to believe a subgroup analysis: revisiting the 11 criteria Journal Articles uri icon · Overview · Research · Identity · Additional Document Info; View All.

When to believe a subgroup analysis: revisiting the 11 criteria

Performing multiple subgroup analyses on a dataset is known to carry the risk of generating spurious results [26] , and we, therefore, focused on one factor ...

Evidence‐based urology in practice: when to believe a subgroup ...

Subgroup analyses are important if there are potentially large differences in treatment effects between subgroups or if there are doubts about ...

A Consumer's Guide to Subgroup Analyses - ACP Journals

The extent to which a clinician should believe and act on the results of subgroup analyses of data from randomized trials or meta-analyses is controversial.

Subgroup Analyses: Subpar or Sublime? | NEJM Evidence - YouTube

This animated video explores some of the potential pitfalls of performing subgroup analyses in randomized controlled trials and explains how ...

Pre-specified vs. post-hoc subgroup analyses: are we wiser before ...

This would indicate stability of a treatment effect over a broad study population. Subgroup analysis could also identify patient subsets with a particular ...

Methods, Challenges, and Best Practices for Conducting Subgroup ...

Important Phases of a Research Study with Subgroup Analysis. Design Phase ... determining which test(s) to trust as true positive(s) can be difficult ...

Interpretation of subgroup analyses in systematic reviews: A tutorial

A statistically significant subgroup effect means that the covariate (trial or patient characteristic) considered in the subgroup analysis statistically ...

Debate: Subgroup analyses in clinical trials: fun to look at - but don't ...

... simply due to the play of chance. When clinicians believe such subgroup analyses, there is a real danger of harm to the individual patient.

based urology in practice: when to believe a subgroup analysis?

Shian-Shiang Wang*†, Yen-Chuan Ou*, Chen-Li Cheng* and Philipp Dahm‡ for the Evidence Based Urology Working Group. *Division of Urology, Department of ...

We believe that the correct interpretation of subgroup findings is closely related to the intrinsic statistical property and validity of the subgroup analysis.

Pooling the data of longest follow up period vs. performing a ...

Whether you pool the studies with differing follow-ups or perform a subgroup analysis is dependent on reasoning within the subject matter.

Justification and reporting of subgroup analyses were lacking or ...

Inappropriate specification and reporting of subgroup analyses remain problematic in protocols and reports of randomized controlled trials. Justifications or ...

Cumulative subgroup analysis to reduce waste in clinical research ...

There are well known limitations with subgroup analyses in RCTs, including possible false positive subgroup effects due to multiple testing, and ...

When to believe a subgroup analysis: revisiting the 11 criteria - OUCI

Sun X, Briel M, Walter SD, Guyatt GH. Is a subgroup effect believable? Updating criteria to evaluate the credibility of subgroup analyses. Bmj 2010;340:c117.