Whole|transcriptome RNA editing analysis in single cortical neurons ...

Whole-transcriptome RNA editing analysis in single cortical neurons ...

The conversion of adenosine to inosine (A>I) in nascent RNA transcripts in the nucleolus by ADAR1 and ADAR2 enzymes, known as 'RNA editing', is ...

Whole-transcriptome RNA editing analysis in single cortical neurons ...

Page 1. Whole-transcriptome RNA editing analysis in single cortical neurons links locus 15q11 with psychiatric illness. 1. 2. Brendan Robert E ...

Whole-transcriptome RNA editing analysis in single ... - OpenAlex

Whole-transcriptome RNA editing analysis in single cortical neurons links locus 15q11 with psychiatric illness ... This 'RNA editing... more. Source ...

A survey of RNA editing at single-cell resolution links interneurons to ...

Inhibitory neurons showed higher overall transcriptome editing than excitatory neurons, and the highest editing rates were observed in the frontal cortex. We ...

Cellular and genetic drivers of RNA editing variation in the human ...

We quantify base-specific RNA editing across three major cell populations from the human prefrontal cortex: glutamatergic neurons, medial ganglionic eminence- ...

RNA and neuronal function: the importance of post-transcriptional ...

The numerous mechanisms of post-transcriptional regulation or translational control of gene expression in the brain include alternative splicing, RNA editing, ...

Whole-transcriptome RNA editing analysis in single cortical neurons ...

Whole-transcriptome RNA editing analysis in single cortical neurons links locus 15q11 with psychiatric illness ... Authors: Brendan Robert E. Ansell; Simon N.

Transcriptome-wide profiling of A-to-I RNA editing by Slic-seq

A-to-I editing is one of the most abundant RNA modifications. It is catalyzed by the enzymes of the ADAR protein family, acting on dsRNA ...

Single-cell transcriptomics reveals specific RNA editing signatures ...

Microfluidic systems coupled with massive mRNA sequencing on dissoci- ated human brain cortex enable the identification of all major neuronal, glial, and ...

Spatiotemporal and genetic regulation of A-to-I editing throughout ...

Posttranscriptional RNA modifications by adenosine-to-inosine (A-to-I) editing are abundant in the brain, yet elucidating functional sites ...

Single-neuron RNA-Seq: technical feasibility and reproducibility

The results demonstrate the technical feasibility and reproducibility of RNA-Seq in capturing a part of the transcriptome landscape of single neurons.

Spatiotemporal mapping of RNA editing in the developing mouse ...

Our single-cell in situ sequencing method has proved useful to study the complex landscape of RNA editing and our results indicate that this ...

Abnormalities in A-to-I RNA editing patterns in CNS injuries ... - Nature

The prevailing concept is that the RNA editing process itself is dysregulated by brain pathologies. Here we analyzed recent RNA-seq data, and ...

An RNA-Sequencing Transcriptome and Splicing Database of Glia ...

We used Ingenuity Pathway Analysis (Ingenuity) to identify signaling pathways and metabolic pathways enriched in each cell type. Genes with FPKM ...

Quantifying RNA Editing in Deep Transcriptome Datasets - Frontiers

Hereafter, we describe a number of important metrics to quantify RNA editing in RNAseq experiments, enabling comparative analysis of whole inosinomes across ...

RNA Editing: A Contributor to Neuronal Dynamics in the Mammalian ...

Recent advances in NGS transcriptome analyses will make it possible to study activity-induced variations in RNA editing that may further explain the complexity ...

Accumulation of nuclear ADAR2 regulates adenosine-to-inosine ...

Highlighted Article: During neuronal maturation, adenosine-to-inosine RNA editing is regulated by nuclear import of the ADAR2 editing enzyme, which is.

Activity-regulated RNA editing in select neuronal subfields in ...

However, although splicing programs respond to external signals, facilitating fine tuning and homeostasis of cellular functions, a similar ...

Subcellular sequencing of single neurons reveals the dendritic ...

Single somata and dendrites of individual rat neurons were laser-captured and sequenced to discover and compare the subcellular ...

RNA editing regulates glutamatergic synapses in the frontal cortex of ...

Functional annotation and pathway analyses identified molecular processes affected by RNA editing alterations. Pearson correlation analyses ...