Why are some cancers unresponsive to checkpoint inhibitors?

"If the immune cells are not in the appropriately activated state, treatment with anti-PD-1 drives these T cells into a dysfunctional, non- ...

Researchers Identify Why Some Cancers Do Not Respond to ...

However, immune checkpoint blockade, a type of cancer immunotherapy that enhances the body's natural immune response against tumor cells, is ...

Study explains why certain immunotherapies don't always work as ...

Cancer drugs known as checkpoint blockade inhibitors have proven effective for some cancer patients. These drugs work by taking the brakes ...

Resistance to immune checkpoint blockade: Mechanisms, counter ...

Cancer immunotherapy seeks to target the immune system against tumor cells and has garnered significant attention as an alternative to traditional ...

Mechanisms of resistance to immune checkpoint inhibitors - Nature

Whereas cytotoxic chemotherapy and small molecule inhibitors ('targeted therapies') largely act on cancer cells directly, immune checkpoint ...

Mechanisms of Resistance to Immune Checkpoint Blockade

Extrinsic resistance occurs external to tumor cells throughout the T-cell activation process. Tumor Immunogenicity. The ability for tumors to ...

Resisting Resistance to Immune Checkpoint Therapy: A Systematic ...

These agents enhance the immune response towards cancer cells instead of targeting the tumor itself, contrary to standard chemotherapy. Although ...

Resistance to Checkpoint Inhibition in Cancer Immunotherapy

The interaction of the host immune system with tumor cells in the tissue microenvironment is essential in understanding tumor immunity and development of ...

Study finds why immunotherapies don't work on hardest-to-treat ...

The process of surviving chemotherapy triggers a program of immune checkpoints that shield breast cancer cells from different lines of attack by ...

Why doesn't immunotherapy work for everyone?

However, checkpoint inhibitors don't yet work for everyone. Certain cancers, including pancreatic cancer, prostate cancer and glioblastoma, have ...

Checkpoint Blockade Immunotherapy - Moffitt Cancer Center

Much like other immunotherapies, the goal of checkpoint blockade immunotherapy is to strengthen the body's immune system and enhance its ability to fight off ...

Checkpoint therapy in cancer treatment: progress, challenges, and ...

PD-1 can also suppress T cell function by inhibiting signaling through CD28 as well as TCR signaling (1). Its blockade relieves the inhibitory ...

Hallmarks of Resistance to Immune-Checkpoint Inhibitors

Oncogene-driven T-cell exclusion is another process by which tumors can shut down antitumor immunity and is evidenced by gain-of-function alterations of the β- ...

Sensitizing immune unresponsive colorectal cancers to immune ...

Immune checkpoint inhibitor (ICI) antibodies targeting PD-1 and PD-L1 have revolutionized the treatment of cancer, triggering long-term regressions in a ...

Immune checkpoint signaling and cancer immunotherapy - Nature

Immune checkpoint blockade therapy has become a major weapon in fighting cancer. Antibody drugs, such as anti-PD-1 and anti-PD-L1, ...

Checkpoint inhibitors | Types of immunotherapy | Cancer Research UK

So the cancer cells are pushing a stop button on the immune system. And the T cells can no longer recognise and kill cancer cells. Drugs that block checkpoint ...

Immune Checkpoint Inhibitors and Their Side Effects

The checkpoints act like switches that need to be turned on (or off) to start an immune response. But cancer cells sometimes find ways to use ...

Immune Checkpoint Inhibitor Cancer Treatment

This therapy is sometimes called immune checkpoint blockade because the molecule that acts as a brake on immune cells — the checkpoint — is blocked by the drug.

Checkpoint Inhibitors | Fred Hutchinson Cancer Center

Cancer cells can trick these checkpoints by sending false signals. This disguises the tumors so that they appear harmless, which puts the brakes on T cells — ...

Checking In on Cancer Checkpoint Inhibitors - NCI

But it's also really important to understand that immune checkpoint inhibitors are not directed against the tumor. They have no direct antitumor ...